| Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. | |
| | |
MedLine Citation:
|
PMID: 12641399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Resistance to chloroquine (CQ) requires its replacement as first-line therapy for uncomplicated malaria in much of Africa. Combination therapy may improve efficacy and delay the selection of resistant malaria parasites. Combinations of sulfadoxine-pyrimethamine (SP) with 4-aminoquinolines offer affordable and available alternatives to CQ. We conducted a randomized, single-blinded trial to compare the efficacy of SP monotherapy with combinations of SP and either CQ or amodiaquine (AQ) for the treatment of uncomplicated falciparum malaria in patients over 6 months of age in Kampala, Uganda. Of the 448 patients enrolled, 428 (95%) completed follow-up. Clinical treatment failure after 14 days occurred in 21/140 (15.0%, 95% CI 9.5-22.0%) SP-treated, 11/152 (7.2%, 95% CI 3.7-12.6%) SP/CQ-treated, and 0/136 (0%, 95% CI 0-2.7%) SP/AQ-treated patients. Combination therapies were safe and offered superior efficacy to SP monotherapy. SP/AQ was the most efficacious. This low-cost combination regimen may provide an optimal alternative to CQ for the treatment of uncomplicated malaria in Uganda. |
| | |
Authors:
|
Anne F Gasasira; Grant Dorsey; Bridget Nzarubara; Sarah G Staedke; Annette Nassali; Philip J Rosenthal; Moses R Kamya |
Related Documents
:
|
16133789 - An open label, non-comparative phase ii study of gemcitabine as salvage treatment for p... 22738289 - Regional citrate anticoagulation in cardiac surgery patients at high risk of bleeding: ... 22298249 - Gastroesophageal reflux disease and postlaryngectomy tracheoesophageal fistula. 22380529 - Randomised clinical trial: the safety and efficacy of long-acting octreotide in patient... 20966629 - The association between health-related quality of life and mortality among hemodialysis... 18347489 - Cosmetic outcomes of absorbable versus nonabsorbable sutures in pediatric facial lacera... 10515339 - Keloids and hypertrophic scars: results with intraoperative and serial postoperative co... 15191479 - Effect of total hip arthroplasty on recreational and sporting activity. 22580859 - Estimation of botulinum toxin type a efficacy on spasticity and functional outcome in c... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 68 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2003 Feb |
Date Detail:
|
Created Date: 2003-03-18 Completed Date: 2003-03-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
|
Languages: eng Pagination: 127-32 Citation Subset: AIM; IM |
Affiliation:
|
Makerere University Medical School, Kampala, Uganda. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Amodiaquine / administration & dosage, therapeutic use* Antimalarials / administration & dosage, therapeutic use* Child Child, Preschool Chloroquine / administration & dosage, therapeutic use* Drug Combinations Drug Therapy, Combination Female Humans Infant Malaria, Falciparum / drug therapy* Male Middle Aged Pyrimethamine / administration & dosage, therapeutic use* Single-Blind Method Sulfadoxine / administration & dosage, therapeutic use* Treatment Outcome Uganda |
| Grant Support | |
ID/Acronym/Agency:
|
AI43301/AI/NIAID NIH HHS; TW00007/TW/FIC NIH HHS; TW01506/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antimalarials; 0/Drug Combinations; 2447-57-6/Sulfadoxine; 37338-39-9/sulfadoxine-pyrimethamine; 54-05-7/Chloroquine; 58-14-0/Pyrimethamine; 86-42-0/Amodiaquine |
| Comments/Corrections | |
Comment In:
|
Am J Trop Med Hyg. 2003 Feb;68(2):125-6
[PMID:
12641398
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional genomics in rat models of hypertension: using differential expression and congenic strain...
Next Document: Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: co...