| Comparative effects of xenon and nitrous oxide on diaphragmatic contractility in dogs. | |
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MedLine Citation:
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PMID: 12059894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Xenon at two different concentrations (30%, 60%) has no effect on diaphragmatic contractility. This study was undertaken to compare the effects of xenon and nitrous oxide (N2O), a commonly used and well-established gas anesthetic, on diaphragmatic contractility in dogs. METHODS: Twenty-one pentobarbitone-anesthetized dogs were randomly divided into three groups of seven each: group 1 received xenon 30% (0.25 MAC) in oxygen; group 2 received N2O 47% (0.25 MAC) in oxygen; and group 3 received N2O 60% (0.32 MAC) in oxygen. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi) at low- (20-Hz) and high-frequency (100-Hz) stimulation, after maintaining 60 min of stable condition. The integrated electrical activity of diaphragm (Edi) to each stimulus was measured. RESULTS: With an inhalation of xenon 30%, N2O 47%, or N2O 60%, Pdi and Edi at both stimuli did not change. No difference in Pdi or Edi was observed among the groups. CONCLUSION: When used at clinical concentration, xenon or N2O does not affect contractility and electrical activity of the diaphragm in dogs. |
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Authors:
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T Hoshi; Y Fujii; H Toyooka |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 46 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-06-12 Completed Date: 2002-10-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 699-702 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Anesthetics, Inhalation / pharmacology* Animals Diaphragm / drug effects*, physiology Dogs Muscle Contraction / drug effects* Nitrous Oxide / pharmacology* Xenon / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 7440-63-3/Xenon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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