Document Detail

Comparative effects of xenon and nitrous oxide on diaphragmatic contractility in dogs.
MedLine Citation:
PMID:  12059894     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Xenon at two different concentrations (30%, 60%) has no effect on diaphragmatic contractility. This study was undertaken to compare the effects of xenon and nitrous oxide (N2O), a commonly used and well-established gas anesthetic, on diaphragmatic contractility in dogs. METHODS: Twenty-one pentobarbitone-anesthetized dogs were randomly divided into three groups of seven each: group 1 received xenon 30% (0.25 MAC) in oxygen; group 2 received N2O 47% (0.25 MAC) in oxygen; and group 3 received N2O 60% (0.32 MAC) in oxygen. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi) at low- (20-Hz) and high-frequency (100-Hz) stimulation, after maintaining 60 min of stable condition. The integrated electrical activity of diaphragm (Edi) to each stimulus was measured. RESULTS: With an inhalation of xenon 30%, N2O 47%, or N2O 60%, Pdi and Edi at both stimuli did not change. No difference in Pdi or Edi was observed among the groups. CONCLUSION: When used at clinical concentration, xenon or N2O does not affect contractility and electrical activity of the diaphragm in dogs.
T Hoshi; Y Fujii; H Toyooka
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  46     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  699-702     Citation Subset:  IM    
Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
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MeSH Terms
Analysis of Variance
Anesthetics, Inhalation / pharmacology*
Diaphragm / drug effects*,  physiology
Muscle Contraction / drug effects*
Nitrous Oxide / pharmacology*
Xenon / pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide; 7440-63-3/Xenon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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