Document Detail

Comparative effects of vasodilator drugs on large and small coronary resistance vessels in the dog.
MedLine Citation:
PMID:  6783305     Owner:  NLM     Status:  MEDLINE    
One of the mechanisms whereby nitroglycerin is considered to reduce myocardial ischaemia and spasm is its preferential reduction of resistance of large compared with small coronary arteries. Accordingly, the action of nitroglycerin on these two resistance beds was compared with newer coronary vasodilator drugs. Following intracoronary administration of boluses of each drug, large and small vessel coronary resistance was measured in 14 dogs by recording the pressure drop across each vascular bed while flow was held constant. The dose of each drug was given to reduce small vessel resistance by 30% (range means 27 to 32%) which peaked at 5 to 10 s and declined to 8 to 18% at 1 min when reduction in large vessel resistance was at its maximum. At 1 min the large vessel resistance was decreased 56 +/- 5% by nitroglycerin, 23 +/- 5% by nitroprusside, 8 +/- 4% by perhexiline, 0 +/- 5% by verapamil and increased 8 +/- 5% by nifedipine. Nitroprusside reduced the large vessel resistance significantly less than nitroglycerin (P < 0.001) for an equivalent reduction in small vessel resistance. Perhexiline, verapamil and nifedipine did not significantly reduce large vessel resistance and the discrepancy between these results and their antianginal and antispasm effect in humans was not apparent from these experiments. However, a suitable model of coronary spasm in the dog following ergonovine injection could not be created.
R Forman; E S Kirk
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  14     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1980 Oct 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
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MeSH Terms
Coronary Vessels / drug effects*,  physiology
Nifedipine / pharmacology
Nitroglycerin / pharmacology
Nitroprusside / pharmacology
Perhexiline / pharmacology
Vascular Resistance / drug effects*
Vasodilator Agents / pharmacology*
Verapamil / pharmacology
Grant Support
23171-02//PHS HHS
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 21829-25-4/Nifedipine; 52-53-9/Verapamil; 55-63-0/Nitroglycerin; 6621-47-2/Perhexiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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