| Comparative effects of two beta-blockers on cardiovascular reactivity and type A behavior in hypertensives. | |
| | |
MedLine Citation:
|
PMID: 2853406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study compared the effects of beta-blockers differing in degree of central nervous system penetration on Type A behavior and cardiovascular reactivity to mental stress. Forty-six male hypertensives were assigned randomly to receive either highly lipophilic and nonselective propranolol, hydrophilic and cardioselective atenolol, the diuretic hydrochlorothiazide, or placebo. Subjects were administered parallel forms of the Structured Interview (SI) and performed mental arithmetic and a cognitive task prior to and after 6 weeks of therapy. Results indicated that diuretic and placebo subjects (subsequently combined into a single control group) did not differ and that both beta-blockers reduced heart rate but not blood pressure reactivity to mental stress (p less than 0.02), an effect that was strongest during the mental arithmetic test. Analysis of SI components indicated a reduction only in explosive speech for beta-blockers versus controls (p less than 0.05). For global SI classifications, seven out of 12 subjects (58%) receiving propranolol, three of 12 (25%) receiving atenolol, and four of 22 control subjects (18%) became less Type A (p less than 0.05). These data do not replicate results of a prior study obtained with atenolol and suggest that only a subset of hypertensive individuals show reduced Type A behavior with propranolol. Central nervous system mechanisms may be important in producing these effects. |
| | |
Authors:
|
D S Krantz; R J Contrada; L A Durel; D R Hill; E Friedler; J D Lazar |
Related Documents
:
|
22498696 - Cardiovascular autonomic neuropathy and subclinical cardiovascular disease in normoalbu... 3402466 - Comparison of acute haemodynamic effects of dopexamine hydrochloride, dobutamine and so... 13496 - Haemodynamic effects of different beta blockers in angina pectoris. 1378146 - Carvedilol in hypertension: effects on hemodynamics and 24-hour blood pressure. 1468556 - Air saturation of the medium reduces the rate of phosphorylating oxidation of succinate... 10977606 - Measurement of arterial compliance in vivo. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Psychosomatic medicine Volume: 50 ISSN: 0033-3174 ISO Abbreviation: Psychosom Med Publication Date: 1988 Nov-Dec |
Date Detail:
|
Created Date: 1989-04-28 Completed Date: 1989-04-28 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 615-26 Citation Subset: IM |
Affiliation:
|
Department of Medical Psychology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arousal / drug effects* Atenolol / therapeutic use* Brain / drug effects Clinical Trials as Topic Double-Blind Method Humans Hydrochlorothiazide / therapeutic use Hypertension / drug therapy*, psychology Male Middle Aged Propranolol / therapeutic use* Prospective Studies Random Allocation Receptors, Adrenergic, beta / drug effects Type A Personality* |
| Grant Support | |
ID/Acronym/Agency:
|
HL31514/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Adrenergic, beta; 29122-68-7/Atenolol; 525-66-6/Propranolol; 58-93-5/Hydrochlorothiazide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of endogenous opioid mediation in stress-induced hypercholesterolemia in the rat.
Next Document: Histamine alters prostaglandin output from diestrous rat uteri. Involvement of H2-receptors and 9-ke...