Document Detail

Comparative effects of synthetic and natural vasoactive intestinal peptide on pancreatic and biliary secretion and on glucose and insulin blood levels in the dog.
MedLine Citation:
PMID:  694415     Owner:  NLM     Status:  MEDLINE    
The effects of synetic porcine vasoactive intestinal peptide (VIP) on pancreatic and biliary secretion and on glucose, insulin and calcium blood levels were examined in the dog and compared with the effects of natural porcine VIP. Synthetic VIP was a secretin-like partial agonist of pancreatic and biliary secretion with efficacies relative to secretin of 0.27 and 0.41, respectively. Consistent with its weak secretin-like action, synthetic VIP augmented the pancreatic response to CCK-OP and the submaximal but not the maximal response to secretin. Synthetic VIP also produced a dose-dependent increase in blood glucose levels and a synchronous and proportionate increase in blood insulin levels. A slight increase in total calcium levels was equivocal. The effects of antural VIP on pancreatic and biliary secretion and on glucose and insulin blood levels were identical to those of synthetic VIP. The identity of effects supports the validity of the postulated structure of porcine VIP. Although elicited at high doses, the effects of VIP on exocrine and endocrine secretion may be relevant physiologically in the context of a neurocrine or paracrine role for VIP.
G M Makhlouf; W M Yau; A M Zfass; S I Said; M Bodanszky
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  13     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  759-65     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / secretion
Bile / secretion*
Blood Glucose* / analysis
Blood Pressure / drug effects
Calcium / blood
Dose-Response Relationship, Drug
Gastrointestinal Hormones / pharmacology*
Heart Rate / drug effects
Insulin / blood*
Liver / drug effects,  secretion*
Pancreas / drug effects,  secretion*
Pancreatic Juice / secretion*
Vasoactive Intestinal Peptide / administration & dosage,  pharmacology*
Reg. No./Substance:
0/Bicarbonates; 0/Blood Glucose; 0/Gastrointestinal Hormones; 11061-68-0/Insulin; 37221-79-7/Vasoactive Intestinal Peptide; 7440-70-2/Calcium

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