Document Detail

Comparative effects of soy and casein protein on plasma cholesterol concentrations.
MedLine Citation:
PMID:  7200345     Owner:  NLM     Status:  MEDLINE    
The effects of soy and casein protein on cholesterol metabolism were determined under normocholesterolemic and hypercholesterolemic conditions in male Wistar rats and in Swiss White mice. Hypercholesterolemia was induced by feeding cholesterol and cholic acid in the diet for a period of 2 weeks. Our results demonstrate that there are significant species differences. The hypercholesterolemic effect of exogenous cholesterol was more pronounced in the mouse than in the rat. The rats fed the basal (no cholesterol, no cholic acid) semisynthetic diet containing either soy or casein had plasma cholesterol concentrations similar to those observed in chow-fed controls. However, plasma cholesterol concentrations in the mice fed the basal semisynthetic diet containing either of the two proteins were significantly elevated compared to the control mice fed commercial chow. Rat data demonstrate that the hypercholesterolemia induced by exogenous cholesterol administration is of a lesser magnitude in the presence of soy compared to casein as a dietary protein source. The mice data show that the concentrations of hepatic and biliary cholesterol and plasma triglycerides and in response to exogenous cholesterol are significantly lower in the soy protein diet compared to the casein protein diet.
K L Raheja; W G Linscheer
Related Documents :
12840195 - Dietary diethylstilbestrol but not genistein adversely affects rat testicular development.
10543025 - Developmental effects of dietary phytoestrogens in sprague-dawley rats and interactions...
17305355 - Antimicrobial paper based on a soy protein isolate or modified starch coating including...
9446845 - Decreased serum total cholesterol concentration is associated with high intake of soy p...
3772825 - Post-ingestive food-aversion learning to amino acid deficient diets by the terrestrial ...
7733795 - Dietary fibre, what it is and how it is measured.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  26     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1982  
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bile / analysis
Caseins / pharmacology*
Cholesterol / blood*
Cholesterol, Dietary / metabolism*
Cholic Acids / pharmacology
Dietary Proteins / metabolism*
Lipids / analysis
Liver / analysis
Rats, Inbred Strains
Soybeans / metabolism*
Species Specificity
Reg. No./Substance:
0/Caseins; 0/Cholesterol, Dietary; 0/Cholic Acids; 0/Dietary Proteins; 0/Lipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oestrogen-induced proteins in breast cancer (author's transl)
Next Document:  Effect of sodium chloride and sorbitol infusions on vascular angiotensin reactivity during third tri...