| Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients. | |
| | |
MedLine Citation:
|
PMID: 20536790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study attempted to establish whether a calcineurin inhibitor (CNI)-free immunosuppressant regimen based on sirolimus (SRL) is associated with a preservation of conduit arteries endothelial function in kidney recipients or not. Twenty-nine kidney recipients were randomized to receive since transplantation SRL (n=15) or cyclosporin A (CsA, n=14) associated with mycophenolate mofetil (MMF) and steroids (6months) in a parallel prospective study. Systolic, diastolic blood pressures, glomerular filtration rate (GFR) and radial artery flow-mediated dilatation (FMD) induced by postischaemic hyperaemia were assessed in a blind manner at one (M1) and 7months (M7) after transplantation. Endothelium-independent dilatation was assessed by glyceryl trinitrate spray. There was no difference between the groups for all vascular parameters at M1. At M7, systolic blood pressure was lower (SRL: 119±3 vs. CsA: 138±4mmHg, P<0.05) and FMD was higher in SRL compared with CsA (SRL: 13.1±0.9 vs. CsA: 9.9±0.9%, P<0.05) without any difference for hyperaemia, endothelium-independent dilatation and GFR (SRL: 66.7±1.05 vs. CsA: 67.5±1.22ml/min). Our results demonstrate that a CNI-free regimen based on SRL and MMF prevents conduit artery endothelial dysfunction compared with CsA and MMF in kidney recipients suggesting a beneficial arterial wall effect that may also contribute to the decrease in systolic blood pressure. |
| | |
Authors:
|
Robinson Joannides; Isabelle Etienne; Michele Iacob; Bruno Hurault de Ligny; Stephane Barbier; Jeremy Bellien; Yvon Lebranchu; Christian Thuillez; Michel Godin |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 23 ISSN: 1432-2277 ISO Abbreviation: Transpl. Int. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-29 Completed Date: 2011-02-18 Revised Date: 2012-07-03 |
Medline Journal Info:
|
Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: England |
Other Details:
|
Languages: eng Pagination: 1135-43 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation. |
Affiliation:
|
Department of Pharmacology, Rouen University Hospital & INSERM U644, Institute for Biomedical Research, University of Rouen, Rouen, France. robinson.joannides@chu-rouen.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Arteries / drug effects Blood Pressure Cyclosporine / therapeutic use* Endothelium, Vascular / drug effects* Female Glomerular Filtration Rate Humans Immunosuppressive Agents / therapeutic use Ischemia / pathology Kidney / drug effects Kidney Transplantation / adverse effects, methods Male Middle Aged Prospective Studies Sirolimus / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Immunosuppressive Agents; 53123-88-9/Sirolimus; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of interleukin-2 receptor antibody therapy on acute rejection risk and severity, long-term re...
Next Document: Suppressing memory T cell activation induces islet allograft tolerance in alloantigen-primed mice.