Document Detail

Comparative effects of sirolimus and cyclosporin on conduit arteries endothelial function in kidney recipients.
MedLine Citation:
PMID:  20536790     Owner:  NLM     Status:  MEDLINE    
This study attempted to establish whether a calcineurin inhibitor (CNI)-free immunosuppressant regimen based on sirolimus (SRL) is associated with a preservation of conduit arteries endothelial function in kidney recipients or not. Twenty-nine kidney recipients were randomized to receive since transplantation SRL (n=15) or cyclosporin A (CsA, n=14) associated with mycophenolate mofetil (MMF) and steroids (6months) in a parallel prospective study. Systolic, diastolic blood pressures, glomerular filtration rate (GFR) and radial artery flow-mediated dilatation (FMD) induced by postischaemic hyperaemia were assessed in a blind manner at one (M1) and 7months (M7) after transplantation. Endothelium-independent dilatation was assessed by glyceryl trinitrate spray. There was no difference between the groups for all vascular parameters at M1. At M7, systolic blood pressure was lower (SRL: 119±3 vs. CsA: 138±4mmHg, P<0.05) and FMD was higher in SRL compared with CsA (SRL: 13.1±0.9 vs. CsA: 9.9±0.9%, P<0.05) without any difference for hyperaemia, endothelium-independent dilatation and GFR (SRL: 66.7±1.05 vs. CsA: 67.5±1.22ml/min). Our results demonstrate that a CNI-free regimen based on SRL and MMF prevents conduit artery endothelial dysfunction compared with CsA and MMF in kidney recipients suggesting a beneficial arterial wall effect that may also contribute to the decrease in systolic blood pressure.
Robinson Joannides; Isabelle Etienne; Michele Iacob; Bruno Hurault de Ligny; Stephane Barbier; Jeremy Bellien; Yvon Lebranchu; Christian Thuillez; Michel Godin
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  23     ISSN:  1432-2277     ISO Abbreviation:  Transpl. Int.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-02-18     Revised Date:  2012-07-03    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1135-43     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation.
Department of Pharmacology, Rouen University Hospital & INSERM U644, Institute for Biomedical Research, University of Rouen, Rouen, France.
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MeSH Terms
Arteries / drug effects
Blood Pressure
Cyclosporine / therapeutic use*
Endothelium, Vascular / drug effects*
Glomerular Filtration Rate
Immunosuppressive Agents / therapeutic use
Ischemia / pathology
Kidney / drug effects
Kidney Transplantation / adverse effects,  methods
Middle Aged
Prospective Studies
Sirolimus / therapeutic use*
Time Factors
Reg. No./Substance:
0/Immunosuppressive Agents; 53123-88-9/Sirolimus; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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