| Comparative effects of secretin (SEC) and cholecystokinin-octapeptide (CCK-8) on pancreatic microcirculation. | |
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MedLine Citation:
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PMID: 7781434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using epifluorescent microscopy, we investigated the dynamic changes in pancreatic microcirculation in vivo after bolus administration of secretin (SEC) (0.1-10.0 micrograms/100 g body wt) and cholecystokinin-octapeptide (CCK-8) (0.005-1.2 micrograms/100 g body wt) in pentobarbital-anesthetized rats. Pancreatic capillary red cell velocity as a monitor for pancreatic capillary blood flow was measured in 1-min intervals from 2 min prior to 8 min following bolus infusion of SEC or CCK-8. Physiological concentrations of SEC did not increase pancreatic capillary blood flow. However, pharmacological SEC concentrations induced a dose-dependent increase in pancreatic capillary blood flow (to 162 +/- 19% of baseline; P < 0.05), due to an increase in blood flow velocity (to 153 +/- 18% of baseline; P < 0.05). In contrast, bolus administration of physiological CCK-8 concentrations, which have been proven to stimulate enzyme secretion, induced a transient and dose-dependent increase in pancreatic capillary blood flow (to 235 +/- 24% of baseline; P < 0.05), due to an increase in blood flow velocity (to 184 +/- 13% of baseline; P < 0.05) and capillary diameters (+0.63 +/- 0.15 micron; P < 0.05). |
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Authors:
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T Plusczyk; M Bauer; I Marzi; G Harbauer; G Feifel |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 40 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-07-19 Completed Date: 1995-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1199-206 Citation Subset: AIM; IM |
Affiliation:
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Department of General Surgery, University of Saarland, Homburg/Saar, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Flow Velocity / drug effects Blood Volume / drug effects Dose-Response Relationship, Drug Erythrocytes / drug effects, physiology Kinetics Male Microcirculation / drug effects Microscopy, Fluorescence / methods Pancreas / blood supply*, drug effects* Rats Rats, Inbred Lew Secretin / pharmacology* Sincalide / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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1393-25-5/Secretin; 25126-32-3/Sincalide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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