| Comparative effects of propranolol and verapamil alone and in combination on left ventricular function and volumes in patients with chronic exertional angina: a double-blind, placebo-controlled, randomized, crossover study with radionuclide ventriculography. | |
| | |
MedLine Citation:
|
PMID: 6315259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
With the use of equilibrium radionuclide ventriculography the effects on left ventricular (LV) function of 160 mg oral propranolol daily and 360 mg verapamil daily alone and in combination were compared in 18 patients with chronic exertional angina. A randomized, double-blind, placebo-controlled, crossover protocol was used. The reduction in exercise rate-pressure product induced by the combination (118 +/- 28 mm Hg/min) was significantly greater (p less than .05) than that by propranolol (135 +/- 27 mm Hg/min) or verapamil alone (163 +/- 28 mm Hg/min). In patients at rest, neither single nor combined therapy altered global or regional left ventricular ejection fractions (EFs). Verapamil, but not propranolol, increased (p less than .05) cardiac volumes of resting subjects; used in combination, no further increase in LV volume occurred. With placebo, exercise global EF did not decrease from the level at rest and therefore no drug effect could be demonstrated for this parameter of LV function. By an evaluation of normalized regional EF measurements the combination was shown to reduce exercise-induced hypokinesis (placebo 52 +/- 20%, combination 61 +/- 23%; p less than .01). No significant improvement was noted with propranolol or verapamil alone; only the combination prevented a significant increase in end-systolic and end-diastolic volumes during exercise. Thus, propranolol and verapamil, used alone in moderate doses, exert no beneficial effect on exercise LV function as measured by EF and volume changes, and resting function deteriorates slightly with verapamil.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
D L Johnston; V A Gebhardt; A Donald; W J Kostuk |
Related Documents
:
|
10715659 - Exercise-induced wall motion abnormalities and resting left ventricular dysfunction in ... 20646909 - Exercise-induced left ventricular systolic dysfunction in women heterozygous for dystro... 2188839 - Changes in cardiovascular function with aging. 1191449 - Effects of sustained isometric handgrip on praecordial accelerocardiogram in normal sub... 1874239 - Cardiovascular response to static handgrip in trained and untrained men. 19782789 - Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseli... 2298189 - Effect of strenuous exercise stress on chemiluminescence response of equine alveolar ma... 2097029 - Effects of setting eggs small end up on hatchability and posthatching performance of br... 9486159 - The effect of exercise training on leptin levels in obese males. |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 68 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1983 Dec |
Date Detail:
|
Created Date: 1984-01-27 Completed Date: 1984-01-27 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1280-9 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Angina Pectoris / drug therapy*, radionuclide imaging Blood Pressure / drug effects Double-Blind Method Drug Therapy, Combination Electrocardiography Female Heart Rate / drug effects Humans Male Middle Aged Myocardial Contraction / drug effects Physical Exertion Propranolol / administration & dosage, therapeutic use* Random Allocation Sodium Pertechnetate Tc 99m Stroke Volume / drug effects Technetium / diagnostic use Verapamil / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
23288-60-0/Sodium Pertechnetate Tc 99m; 52-53-9/Verapamil; 525-66-6/Propranolol; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Unitary sodium channels in isolated cardiac myocytes of rabbit.
Next Document: The effect of substituted sydnonimines on coronary smooth muscle relaxation and cyclic guanosine mon...