Document Detail

Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients.
MedLine Citation:
PMID:  11113686     Owner:  NLM     Status:  MEDLINE    
Urinary endothelin (ET)-1 excretion is present in non-insulin dependent diabetes (NIDDM) patients with microalbuminuria, and an increase in circulating ET-1 precedes the microalbuminuric phase of renal injury related to diabetes. The aim of the present study was to determine whether various drugs alter urinary ET-1 levels and urinary albumin excretion (UAE) in NIDDM patients with microalbuminuria. Forty-five NIDDM patients with microalbuminuria were randomly assigned to three groups: those treated with pioglitazone at 30 mg/day (n=15), those treated with glibenclamide at 5 mg/day (n=15), and those treated with voglibose at 0.6 mg/day (n=15). Patients received these drugs for 3 months. UAE, urinary ET-1, and plasma ET-1 levels were measured in these patients before and after treatment. Before treatment, UAE, urinary ET-1, and plasma ET-1 levels differed little among the three groups. UAE in the 45 NIDDM patients (156.2+/-42.8 microg/min) was greater than that in 30 healthy controls (8.2+/-2.6 microg/min) (P<.001). Urinary ET-1 levels in the NIDDM patients (8.7+/-1.3 ng/g urinary creatinine (UC)) were significantly higher than that in the controls (2.4+/-0.2 ng/g UC) (P<.01). Plasma ET-1 levels, however, in the NIDDM patients (1.3+/-0.4 pg/ml) did not differ significantly from the levels in healthy controls (1.0+/-0.6 pg/ml). Pioglitazone but no glibenclamide or voglibose reduced UAE from 142.8+/-42.2 to 48. 4+/-18.2 microg/min (P<.01) and urinary ET-1 levels from 8.6+/-1.3 to 3.4+/-0.5 ng/g UC (P<.01). These data suggest pioglitazone to be effective in reducing UAE and urinary ET-1 concentrations in NIDDM patients with microalbuminuria.
T Nakamura; C Ushiyama; N Shimada; K Hayashi; I Ebihara; H Koide
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of diabetes and its complications     Volume:  14     ISSN:  1056-8727     ISO Abbreviation:  J. Diabetes Complicat.     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204583     Medline TA:  J Diabetes Complications     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  250-4     Citation Subset:  IM    
Department of Medicine, Misato Junshin Hospital, 745 Kobo, Saitama, Misato, Japan.
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MeSH Terms
Blood Pressure / drug effects
Diabetes Mellitus, Type 2 / drug therapy*,  physiopathology,  urine*
Endothelin-1 / urine*
Enzyme Inhibitors / pharmacology,  therapeutic use
Glyburide / pharmacology,  therapeutic use*
Hemoglobin A, Glycosylated / metabolism
Hypoglycemic Agents / pharmacology,  therapeutic use*
Inositol / analogs & derivatives*,  pharmacology,  therapeutic use
Middle Aged
Reference Values
Thiazoles / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Endothelin-1; 0/Enzyme Inhibitors; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Thiazoles; 0/Thiazolidinediones; 10238-21-8/Glyburide; 111025-46-8/pioglitazone; 6917-35-7/Inositol; 83480-29-9/voglibose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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