| Comparative effects of olmesartan and azelnidipine on atrial structural remodeling in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 19440002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The differential effects between olmesartan (OM), an angiotensin 2 type 1 receptor blocker (ARB), and azelnidipine (AZ), a calcium channel blocker (CCB), on atrial structural remodeling were studied in spontaneously hypertensive rats (SHR). Eight weeks after treatment, both OM and AZ decreased systolic blood pressure to similar levels. Histological analysis revealed that both OM and AZ had decreased the size of the atrial myocytes and interstitial fibrosis in the atrium, and that the effects of OM were greater than those of AZ. These beneficial effects of OM were associated with less atrial oxidative stress, as assessed by 3-nitrotyrosine staining, and less activation of Rac1, a regulatory component in NADPH oxidase. These results suggest that the ARB was more effective than the CCB in ameliorating atrial structural remodeling due to the suppression of oxidative stress. |
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Authors:
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Kazuki Okamura; Masahiro Ito; Komei Tanaka; Masaomi Chinushi; Takeshi Adachi; Wataru Mitsuma; Satoru Hirono; Mikio Nakazawa; Makoto Kodama; Yoshifusa Aizawa |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-13 |
Journal Detail:
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Title: Pharmacology Volume: 83 ISSN: 1423-0313 ISO Abbreviation: Pharmacology Publication Date: 2009 |
Date Detail:
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Created Date: 2009-06-09 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 360-6 Citation Subset: IM |
Copyright Information:
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Copyright 2009 S. Karger AG, Basel. |
Affiliation:
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Division of Cardiology, Niigata University Graduate School of Medicine and Dental Sciences, Niigata, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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pharmacology* Animals Azetidinecarboxylic Acid / analogs & derivatives*, pharmacology Blood Pressure / drug effects Calcium Channel Blockers / pharmacology* Dihydropyridines / pharmacology* Heart / anatomy & histology, drug effects Heart Atria / anatomy & histology*, drug effects*, metabolism Imidazoles / pharmacology* Myocytes, Cardiac / cytology, drug effects Oxidative Stress / drug effects Rats Rats, Inbred SHR Tetrazoles / pharmacology* rac1 GTP-Binding Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Imidazoles; 0/Tetrazoles; 0/olmesartan; 123524-52-7/azelnidipine; 2517-04-6/Azetidinecarboxylic Acid; EC 3.6.5.2/rac1 GTP-Binding Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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