Document Detail

Comparative effects of morphine, meperidine and pentazocine on cardiocirculatory dynamics in patients with acute myocardial infarction.
MedLine Citation:
PMID:  937355     Owner:  NLM     Status:  MEDLINE    
The cardiocirculatory effects of the commonly used parenteral analgesics, morphine sulfate 15 mg, meperidine hydrochloride 100 mg and pentazocine 60 mg, each administered intravenously, were compared in 12 patients with acute myocardial infarction during cardiac catheterization and by echocardiogram. No untoward hemodynamic effects occurred following the administration of morphine or meperidine. In contrast, pentazocine produced significant (p less than 0.01 to less than 0.05) increases in systemic and pulmonary arterial pressures, left ventricular filling pressure, systemic vascular resistance, and systolic and diastolic dimensions; and decreases in left ventricular ejection fraction and mean velocity of circumferential fiber shortening. These deleterious actions of pentazocine appeared due to peripheral vasoconstriction and negative inotropic properties. Further, pentazocine-induced increases in left ventricular preload and afterload increased myocardial oxygen demands. Since this study demonstrates that pentazocine is hazardous in myocardial infarction, morphine and meperidine are the preferred analgesics in this condition.
G Lee; A N DeMaria; E A Amsterdam; F Realyvasquez; J Angel; S Morrison; D T Mason
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  60     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-08-23     Completed Date:  1976-08-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  949-55     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Meperidine / pharmacology*,  therapeutic use
Middle Aged
Morphine / pharmacology*,  therapeutic use
Myocardial Infarction / drug therapy*
Pentazocine / pharmacology*,  therapeutic use
Respiration / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
359-83-1/Pentazocine; 57-27-2/Morphine; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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