Document Detail

Comparative effects of ionic anc nonionic contrast materials on coronary and peripheral blood flow.
MedLine Citation:
PMID:  7118518     Owner:  NLM     Status:  MEDLINE    
Contrast materials may alter coronary blood flow (CBF) by a direct vasodilating action or indirectly by changing determinants of myocardial oxygen requirements (MVO2). The current study compared the vasodilatory actions of ionic (Renografin 76, R76) and nonionic contrast materials (iohexol and metrizamide) after direct injection into the coronary and femoral circulation of anesthetized dogs. R76 did not cause a significantly greater increase in CBF compared with nonionic materials in spite of causing significantly greater increases in osmolality of blood in the coronary sinus. Concomitant with the peak increase in CBF, the ionic materials caused sharp decrease in peak left ventricular (LV) systolic pressure and dp/dt, while the nonionic materials increased these major determinants of MVO2. In contradistinction to the effects on CBF, ionic contrast material caused substantially and significantly greater increase in femoral blood flow, compared with the nonionic materials. In conclusion, these studies infer that the increase in CBF with contrast materials involves both indirect vascular and metabolic actions, while the increase in FBF is due to a direct vascular action.
K H Gerber; C B Higgins
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative radiology     Volume:  17     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1982 May-Jun
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  292-8     Citation Subset:  IM    
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MeSH Terms
Blood Circulation / drug effects*
Contrast Media / pharmacology*
Coronary Circulation / drug effects*
Diatrizoate / pharmacology
Diatrizoate Meglumine / pharmacology
Drug Combinations / pharmacology
Femoral Artery / physiology
Heart Rate / drug effects
Metrizamide / pharmacology
Osmolar Concentration
Regional Blood Flow / drug effects
Triiodobenzoic Acids / pharmacology
Grant Support
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 0/Triiodobenzoic Acids; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 31112-62-6/Metrizamide; 66108-95-0/Iohexol; 8064-12-8/urovision

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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