| Comparative effects of hypotension due to isoflurane, nitroglycerin, and adenosine on subendocardial microcirculation: observation of the in situ beating swine heart under critical stenosis. | |
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MedLine Citation:
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PMID: 9286899 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although isoflurane may cause subendocardial hypoperfusion in the presence of coronary stenosis because of its coronary arteriolar dilatory effects, it is not known how the subendocardial microcirculation is affected. The authors examined the effects of isoflurane on poststenotic subendocardial microvessels with coronary stenosis. METHODS: The authors observed subendocardial microvessels in in situ beating swine hearts with or without critical stenosis of the left anterior descending coronary artery (LAD) with a needle-type videomicroscope during isoflurane- (ISO-H), adenosine- (ADE-H), and nitroglycerin- (NTG-H) induced hypotension (mean arterial pressure, 55 mmHg). Regional myocardial function, oxygen balance, and lactate metabolism in the region perfused by the LAD also were determined. RESULTS: In swine with stenosis, there were no differences in heart rate, cardiac output, and LAD blood flow among the three types of hypotension. Regional lactate production and anterior interventricular venous pO2 were similar during ISO-H and NTG-H but higher during ADE-H. With videomicroscopy, about half as many subendocardial microvessels could be visualized during ADE-H as with ISO-H and NTG-H. The average decrease in the systolic diameter of subendocardial microvessels of greater than 100 microm was 9 +/- 6% during ISO-H and 12 +/- 5% during NTG-H, but no consistent phasic diameter changes were observed during ADE-H. In swine without stenosis, a systolic diameter decrease was observed during all three types of hypotension. CONCLUSIONS: These findings suggest that hypotension induced by isoflurane or nitroglycerin preserves phasic diameter changes in subendocardial microvessels in the presence of critical coronary stenosis, whereas that induced by adenosine does not. |
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Authors:
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Y Fujita; H Habazettl; C O Corso; K Messmer; T Yada |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesiology Volume: 87 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-09-25 Completed Date: 1997-09-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 343-53 Citation Subset: AIM; IM |
Affiliation:
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Institute for Surgical Research, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany. fujitay@med.kawasaki-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology* Animals Blood Pressure / drug effects* Coronary Disease / physiopathology* Endocardium Female Hemodynamics / drug effects Hydrogen-Ion Concentration Isoflurane / pharmacology* Male Microcirculation / drug effects Nitroglycerin / pharmacology* Swine |
| Chemical | |
Reg. No./Substance:
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26675-46-7/Isoflurane; 55-63-0/Nitroglycerin; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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