Document Detail


Comparative effects of halothane and isoflurane anesthesia on the ultrastructure of human hepatic cells.
MedLine Citation:
PMID:  2782649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of halothane and isoflurane on the ultrastructure of the liver cells in adult patients with normal liver-function tests were compared. After induction of anesthesia with thiopental, fentanyl, and pancuronium, 18 patients were randomly divided into three groups of six each. Anesthesia was maintained with droperidol (droperidol group), with halothane (1.7 MAC, halothane group), or with isoflurane (1.7 MAC, isoflurane group). During the surgical procedure, 1 hr after the induction, a liver biopsy was performed in each patient and processed for light and electron microscopy. All biopsies were normal on light microscopy. On electron microscopy, no mitochondrial abnormalities were found. In all three groups, irregular nuclear membranes, dilation of the rough endoplasmic reticulum, and vesiculation of the smooth endoplasmic reticulum were seen, without any significant differences between the groups. There were significantly more lysosomes in the hepatocytes of patients receiving halothane than in the hepatocytes of patients receiving isoflurane or droperidol. This study shows that halothane can induce ultrastructure abnormalities very early after the beginning of its administration while, under the same conditions, isoflurane does not.
Authors:
G Goldfarb; E Rogier; C Gebauer; C Lassen; D Bernau; P Jolis; G Feldmann
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  69     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-10-18     Completed Date:  1989-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-5     Citation Subset:  AIM; IM    
Affiliation:
Département d'Anesthesiologie, Hôpital Beaujon, Clichy, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cholecystectomy
Endoplasmic Reticulum / drug effects
Gastrectomy
Halothane / adverse effects*
Humans
Isoflurane / adverse effects*
Liver / cytology,  drug effects*,  ultrastructure
Middle Aged
Mitochondria, Liver / drug effects
Random Allocation
Chemical
Reg. No./Substance:
151-67-7/Halothane; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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