Document Detail

Comparative effects of halothane and isoflurane anesthesia on the ultrastructure of human hepatic cells.
MedLine Citation:
PMID:  2782649     Owner:  NLM     Status:  MEDLINE    
The effects of halothane and isoflurane on the ultrastructure of the liver cells in adult patients with normal liver-function tests were compared. After induction of anesthesia with thiopental, fentanyl, and pancuronium, 18 patients were randomly divided into three groups of six each. Anesthesia was maintained with droperidol (droperidol group), with halothane (1.7 MAC, halothane group), or with isoflurane (1.7 MAC, isoflurane group). During the surgical procedure, 1 hr after the induction, a liver biopsy was performed in each patient and processed for light and electron microscopy. All biopsies were normal on light microscopy. On electron microscopy, no mitochondrial abnormalities were found. In all three groups, irregular nuclear membranes, dilation of the rough endoplasmic reticulum, and vesiculation of the smooth endoplasmic reticulum were seen, without any significant differences between the groups. There were significantly more lysosomes in the hepatocytes of patients receiving halothane than in the hepatocytes of patients receiving isoflurane or droperidol. This study shows that halothane can induce ultrastructure abnormalities very early after the beginning of its administration while, under the same conditions, isoflurane does not.
G Goldfarb; E Rogier; C Gebauer; C Lassen; D Bernau; P Jolis; G Feldmann
Related Documents :
21518599 - Effects of statins on the liver: clinical analysis of patients with ischemic stroke.
21315839 - Prevalence and characteristics of asymptomatic excessive transmural injury following ra...
18379139 - Retrospective evaluation of serum markers apri and ast/alt for assessing liver fibrosis...
2702459 - Intraperitoneal rupture of amoebic liver abscess.
20407889 - Zoledronic acid-induced transient hepatotoxicity in a patient effectively treated for p...
7733609 - Prevalence of hepatobiliary dysfunction in patients with ulcerative colitis.
750609 - Thyroid stimulating antibodies in patients with subacute thyroiditis.
6331819 - Chorioretinal scars in fuchs' heterochromic iridocyclitis.
16223659 - Factors that predicted change in health-related quality of life were identified in a co...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  69     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-10-18     Completed Date:  1989-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-5     Citation Subset:  AIM; IM    
Département d'Anesthesiologie, Hôpital Beaujon, Clichy, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Endoplasmic Reticulum / drug effects
Halothane / adverse effects*
Isoflurane / adverse effects*
Liver / cytology,  drug effects*,  ultrastructure
Middle Aged
Mitochondria, Liver / drug effects
Random Allocation
Reg. No./Substance:
151-67-7/Halothane; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Assessment of spontaneous ventilation in anesthetized children with use of a pediatric circle or a J...
Next Document:  Effect of injection rate on level and duration of hypobaric spinal anesthesia.