| Comparative effects of halothane, enflurane, and methoxyflurane on the incidence of abnormal development using sea urchin gametes as an in vitro model system. | |
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MedLine Citation:
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PMID: 4037379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of sea urchin embryos developing abnormally after their exposure to equimolar concentrations of halothane, enflurane, and methoxyflurane has been determined. Halothane concentrations in the 0.6-1.25 mM range caused 18-96% of the embryos to undergo abnormal cleavage at the first cell division. This is important because embryos exhibiting atypical cleavage patterns at the first cell division eventually involute and die before reaching gastrulation. Over the same range of concentrations, enflurane and methoxyflurane have minimal effects on development. However, when exposed to 2.5 mM methoxyflurane, nearly 40% of the cells did not fertilize. These results show that volatile anesthetic agents have decidedly different effects on development and suggest that the incidence of abnormal development may not correlate directly with the anesthetic potency of inhalational agents. |
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Authors:
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R E Hinkley; B D Wright |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 64 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1985 Oct |
Date Detail:
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Created Date: 1985-10-21 Completed Date: 1985-10-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1005-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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embryology Animals Cell Division / drug effects Embryo, Nonmammalian / cytology, drug effects* Enflurane / toxicity* Female Halothane / toxicity* Male Methoxyflurane / toxicity* Models, Biological Ovum / drug effects Prophase / drug effects Sea Urchins Spermatozoa / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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GM 31723/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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13838-16-9/Enflurane; 151-67-7/Halothane; 76-38-0/Methoxyflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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