Document Detail

Comparative effects of diltiazem sustained-release formulation and metoprolol on ambulatory blood pressure and plasma lipoproteins.
MedLine Citation:
PMID:  2401129     Owner:  NLM     Status:  MEDLINE    
We compared the effects of diltiazem sustained-release formulation and metoprolol on diurnal ambulatory blood pressure (BP) and plasma lipoprotein levels. Forty-nine patients with primary hypertension were included in a randomized, double-blind, crossover study, and 44 completed the trial. Both diltiazem and metoprolol significantly lowered office (p less than 0.001) and diurnal ambulatory BP (p less than 0.01). After 16 weeks of therapy with diltiazem, mean ambulatory BP decreased 10/7 mm Hg, whereas metoprolol lowered BP by 16/10 mm Hg (p less than 0.001 for systolic BP and p less than 0.01 for diastolic BP). Moreover, metoprolol seemed to induce a greater reduction in morning BP at work. Although diltiazem had no effect on lipid levels, treatment with metoprolol was associated with a significant rise in triglyceride levels (p less than 0.001 vs baseline and diltiazem), total cholesterol levels (p less than 0.05 vs baseline), atherogenic index (p less than 0.05 vs baseline and diltiazem) and very low-density lipoprotein and cholesterol levels (p less than 0.001 vs baseline and diltiazem) and a significant decrease in high-density lipoprotein cholesterol levels (p less than 0.01 vs baseline and p less than 0.001 vs diltiazem). These data suggest that both diltiazem and metoprolol provide adequate office BP control. The deleterious effects of metoprolol on lipid and lipoprotein levels may counterbalance its beneficial effects on reduction of ambulatory BP.
Y Lacourcière; L Poirier; S Boucher; J Spenard
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  48     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-22     Completed Date:  1990-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  318-24     Citation Subset:  AIM; IM    
Hypertension Research Unit, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
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MeSH Terms
Ambulatory Care
Blood Pressure / drug effects*
Delayed-Action Preparations
Diltiazem / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Drug Administration Schedule
Hypertension / drug therapy*
Lipoproteins / blood*
Metoprolol / adverse effects,  therapeutic use*
Middle Aged
Random Allocation
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Lipoproteins; 37350-58-6/Metoprolol; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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