| Comparative effects of dietary administered transgenic and conventional papaya on selected intestinal parameters in rat models. | |
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MedLine Citation:
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PMID: 19690973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transformation of agricultural crops with novel genes has significantly advanced disease-resistance breeding, including virus resistance through the expression of virus sequences. In this study, the effects of long-term, repeated exposure to transgenic papayas carrying the coat protein gene of Papaya ringspot virus and conventional non-transgenic papaya on the histology and selected biochemical parameters of the intestinal tract were compared. For 3 months, male and female Wistar rats received diets containing transgenic or non-transgenic papaya at twice the equivalent of the average daily consumption of fresh papayas. Gross and macroscopic appearance of intestinal tissues, as well as stomach tissues, was comparable (P < 0.05) as were total intestinal bacterial counts and activities of beta-glucuronidase. Activities of disaccharidases were not affected, neither were those of amylase (P < 0.05). Although significant differences were noted in the activity of Ca(2+) and Na(+)/K(+) ATPase brush border enzymes, no morphological alteration in the integrity of the intestinal mucosa was found. Overall, negligible effects on feed intake, body weight, and fecal output were observed (P < 0.05). Taken together, long-term exposure to diets formulated with transgenic papaya did not result in biologically important unintended effects. |
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Authors:
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Melissa Powell; Andrew O Wheatley; Felix Omoruyi; Helen N Asemota; Nadia P Williams; Paula F Tennant |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-19 |
Journal Detail:
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Title: Transgenic research Volume: 19 ISSN: 1573-9368 ISO Abbreviation: Transgenic Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9209120 Medline TA: Transgenic Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 511-8 Citation Subset: IM |
Affiliation:
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Department of Basic Medical Sciences, Biochemistry Section, University of the West Indies, Mona, Jamaica. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amylases
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metabolism Animal Feed / adverse effects, virology* Animals Calcium / metabolism Carica / genetics, virology* Disaccharidases / metabolism Female Gastrointestinal Tract / metabolism*, pathology, virology Glucuronidase / metabolism Male Microvilli / enzymology Plants, Genetically Modified / genetics, virology* Potyvirus* Rats Rats, Wistar Sodium-Potassium-Exchanging ATPase / metabolism |
| Chemical | |
Reg. No./Substance:
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7440-70-2/Calcium; EC 3.2.1.-/Amylases; EC 3.2.1.-/Disaccharidases; EC 3.2.1.31/Glucuronidase; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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