| Comparative effects of cilostazol and other therapies for intermittent claudication. | |
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MedLine Citation:
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PMID: 11434896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many patients with peripheral arterial disease (PAD) have intermittent claudication or problems with ambulation and mobility. Exercise and smoking cessation are primary therapies for claudication, but drug treatment may provide additional benefit. The data supporting use of pentoxifylline for claudication are weak, and pentoxifylline is not generally accepted as efficacious. Cilostazol is a new drug for the treatment of claudication. It appears to modestly benefit walking ability and it has other potentially useful effects, including inhibition of platelet aggregation and beneficial effects on serum lipids. In a randomized, prospective, double-blind trial examining walking ability in patients with PAD with moderate-to-severe claudication, cilostazol was superior to both placebo and pentoxifylline. |
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Authors:
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D L Dawson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: The American journal of cardiology Volume: 87 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-03 Completed Date: 2001-08-09 Revised Date: 2013-05-30 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 19D-27D Citation Subset: AIM; IM |
Affiliation:
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Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA. ddawson@bcm.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Intermittent Claudication / diagnosis, drug therapy* Pentoxifylline / therapeutic use* Platelet Aggregation Inhibitors / therapeutic use* Randomized Controlled Trials as Topic Tetrazoles / therapeutic use* Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 0/Tetrazoles; 0/Vasodilator Agents; 6493-05-6/Pentoxifylline; N7Z035406B/cilostazol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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