Document Detail

Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model.
MedLine Citation:
PMID:  15302989     Owner:  NLM     Status:  MEDLINE    
Angiotensin II receptor blockers could prevent the development of atherosclerosis beyond reducing blood pressure in monkeys fed a high-cholesterol diet. However, it has been unclear whether hypotensive effects improve atherosclerosis in primates. We investigated whether antihypertensive agents, an angiotensin II receptor antagonist, candesartan, and a calcium channel blocker, amlodipine, prevent areas of atherosclerotic lesions in the aorta of monkeys fed a high-cholesterol diet. Seventeen male monkeys fed a high-cholesterol diet for 6 months were grouped as follows: a high-cholesterol diet group (n=5), a candesartan-treated group (1 mg/kg per day, n=6) and an amlodipine-treated group (5 mg/kg per day, n=6). Candesartan and amlodipine showed a similar hypotensive effect by decreasing the systolic blood pressure approximately 20 mmHg, while these agents did not affect serum cholesterol levels. The ratio of atherosclerotic area to total area in thoracic aorta was significantly decreased by treatment with candesartan, but the ratio tended to be decreased by treatment with amlodipine. Although the angiotensin-converting enzyme activity in plasma was not changed by treatment with candesartan or amlodipine, the angiotensin-converting enzyme activity in the thoracic aorta was obviously reduced by treatment with candesartan, but not with amlodipine. Therefore, a blockade of angiotensin II action rather than a hypotensive effect may play an important role in preventing the development of atherosclerosis in primates.
Shinji Takai; Denan Jin; Masato Sakaguchi; Michiko Muramatsu; Kenji Ishii; Kazuyoshi Kirimura; Hiroshi Sakonjo; Mizuo Miyazaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  27     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-08-10     Completed Date:  2005-02-14     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Lippincott Williams & Wilkins
Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.
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MeSH Terms
Amlodipine / pharmacology*
Angiotensin II Type 1 Receptor Blockers / antagonists & inhibitors*
Antihypertensive Agents / pharmacology*
Aorta / drug effects,  pathology
Aortic Diseases / pathology,  prevention & control*
Arteriosclerosis / pathology,  prevention & control*
Benzimidazoles / pharmacology*
Calcium Channel Blockers / pharmacology*
Cholesterol / blood
Cholesterol, Dietary / administration & dosage
Macaca fascicularis
Peptidyl-Dipeptidase A / blood
Renin / blood
Tetrazoles / pharmacology*
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Calcium Channel Blockers; 0/Cholesterol, Dietary; 0/Tetrazoles; 57-88-5/Cholesterol; 88150-42-9/Amlodipine; EC A; EC; S8Q36MD2XX/candesartan

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