| Comparative effects of aspartate and glutamate during myocardial ischemia. | |
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MedLine Citation:
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PMID: 6118886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of amino acids aspartate (Asp) and glutamate (Glu) on recovery of contractile function and preservation of compliance were studied in globally ischemic, isolated, blood-perfused cat hearts. Ischemia-induced declines in contractility and compliance were measured with an intraventricular fluid-filled balloon. Asp and Glu were delivered to isolated hearts in physiological salt solution (PSS) containing 10 mM glucose, just prior to, and intermittently during (every 15 min for 1 min) 1 h of normothermic ischemia. Isolated hearts which received Asp and Glu showed recoveries of left ventricular (LV) developed pressure of 79 +/- 8 and 50 +/- 7% of their preischemic values, respectively, compared to 34 +/- 7% in hearts perfused only with PSS. These alterations of contractile function were paralleled by changes in LV compliance. The addition of amino-oxyacetate, and aminotransferase inhibitor, to Asp- containing PSS markedly attenuated the beneficial effects of this amino acid. The results indicate that certain amino acids can protect the ischemic myocardium, presumably through effects on intermediary metabolism. |
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Authors:
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L R Bush; S Warren; C L Mesh; B R Lucchesi |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology Volume: 23 ISSN: 0031-7012 ISO Abbreviation: Pharmacology Publication Date: 1981 |
Date Detail:
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Created Date: 1982-02-22 Completed Date: 1982-02-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 297-304 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartic Acid / therapeutic use* Blood Pressure / drug effects Cats Coronary Disease / drug therapy*, physiopathology Glutamates / therapeutic use* Glutamic Acid Myocardial Contraction |
| Grant Support | |
ID/Acronym/Agency:
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19782-03//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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