Document Detail

Comparative effects of aspartate and glutamate during myocardial ischemia.
MedLine Citation:
PMID:  6118886     Owner:  NLM     Status:  MEDLINE    
The effects of amino acids aspartate (Asp) and glutamate (Glu) on recovery of contractile function and preservation of compliance were studied in globally ischemic, isolated, blood-perfused cat hearts. Ischemia-induced declines in contractility and compliance were measured with an intraventricular fluid-filled balloon. Asp and Glu were delivered to isolated hearts in physiological salt solution (PSS) containing 10 mM glucose, just prior to, and intermittently during (every 15 min for 1 min) 1 h of normothermic ischemia. Isolated hearts which received Asp and Glu showed recoveries of left ventricular (LV) developed pressure of 79 +/- 8 and 50 +/- 7% of their preischemic values, respectively, compared to 34 +/- 7% in hearts perfused only with PSS. These alterations of contractile function were paralleled by changes in LV compliance. The addition of amino-oxyacetate, and aminotransferase inhibitor, to Asp- containing PSS markedly attenuated the beneficial effects of this amino acid. The results indicate that certain amino acids can protect the ischemic myocardium, presumably through effects on intermediary metabolism.
L R Bush; S Warren; C L Mesh; B R Lucchesi
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology     Volume:  23     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1981  
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  297-304     Citation Subset:  IM    
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MeSH Terms
Aspartic Acid / therapeutic use*
Blood Pressure / drug effects
Coronary Disease / drug therapy*,  physiopathology
Glutamates / therapeutic use*
Glutamic Acid
Myocardial Contraction
Grant Support
19782-03//PHS HHS
Reg. No./Substance:
0/Glutamates; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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