Document Detail

Comparative effects of ajmaline on intermittent bundle branch block and the Wolff-Parkinson-White syndrome.
MedLine Citation:
PMID:  857627     Owner:  NLM     Status:  MEDLINE    
Phase 4 or phase 3 block or both occurred in the His bundle branch system of 11 patients with intermittent bundle branch block and in the anomalous bundle of 6 of 46 patients with the Wolff-Parkinson-White syndrome (13%). Administration of a single dose of ajmaline (50 mg intravenously) in these patients caused a similar response: expansion of the range of phase 3 and phase 4 block at the expense of the intermediate normal conduction range and total interruption of conduction in the affected fascicle when the effect of the drug was maximal. The great similarity in physiologic behavior and pharmacologic response in these groups of patients suggests that the anomalous bundle was probably diseased or abnormal in the six patients with Wolff-Parkinson-White conduction. In addition, ajmaline caused the first appearance of phase 4 or phase 3 block, or both, but not total interruption of conduction in 26 of the 46 patients with Wolff-Parkinson-White conduction (56.5%). Ajmaline does not cause fascicular block in normal subjects; thus this finding suggests either that the anomalous bundle is diseased or that the safety margin for conduction in the anomalous bundle is much narrower than in the bundle branch system. The conduction-depressing action of ajmaline may be greater at relatively rapid or relatively slow rates of stimulation, and smaller or absent at intermediate rates.
P A Chiale; J Przybylski; M S Halpern; J O Lazzari; M V Elizari; M B Rosenbaum
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  39     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-11     Completed Date:  1977-06-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  651-7     Citation Subset:  AIM; IM    
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MeSH Terms
Ajmaline / administration & dosage,  diagnostic use*
Bundle-Branch Block / physiopathology*
Depression, Chemical
Heart Conduction System / drug effects,  physiopathology*
Wolff-Parkinson-White Syndrome / physiopathology*
Reg. No./Substance:

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