Document Detail

Comparative effectiveness of the tumour diagnostics, CA 19-9, CA 125 and carcinoembryonic antigen in patients with diseases of the digestive system.
MedLine Citation:
PMID:  3471687     Owner:  NLM     Status:  MEDLINE    
Serum concentrations of CA 19-9, CA 125 and carcinoembryonic antigen (CEA) in 145 patients with gastrointestinal carcinomas and 89 with non-neoplastic diseases were determined to compare the clinical usefulness of these tumour markers. Significantly fewer positive cases were obtained with serum CA 19-9 (9%) and CA 125 (8%) tests than the CEA test (22%) (both p less than 0.05) in patients with benign diseases, while comparable sensitivities were achieved with the CA 19-9 (44%) test, the CA 125 (41%) test and the CEA test (47%) in those with a carcinoma. High incidences of raised concentrations of serum CA 19-9 and CA 125 were observed in case of cancer of the pancreas (CA 19-9: 87%, CA 125: 67%) and biliary tract (CA 19-9: 63%, CA 125: 48%). Combined tests of CA 19-9 and CA 125 revealed increments in the sensitivity (61%) and provided a higher specificity (87%) than that of the single CEA test (78%). These combined tests were most useful for a differential diagnosis of pancreatic carcinoma (97% positive) and biliary tract carcinoma (74%) from chronic pancreatitis (4%) and cholelithiasis (0%), respectively. Studies on the relations of clinical staging and serum concentrations of CA 19-9 and CA 125 revealed significant rises in cases of disseminated carcinoma. These results clearly show that serum CA 19-9 and CA 125 tests are most pertinent for diagnosing advanced carcinomas of organs in the digestive system.
K Sakamoto; Y Haga; R Yoshimura; H Egami; Y Yokoyama; M Akagi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gut     Volume:  28     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-05     Completed Date:  1987-06-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  AIM; IM    
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MeSH Terms
Antigens, Neoplasm / analysis*
Antigens, Tumor-Associated, Carbohydrate
Carcinoembryonic Antigen / analysis*
Digestive System Diseases / diagnosis*,  immunology
Digestive System Neoplasms / diagnosis,  immunology
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Antigens, Tumor-Associated, Carbohydrate; 0/Carcinoembryonic Antigen

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