Document Detail


Comparative effect of tiaprofenic acid and piroxicam alone and as adjuvants to praziquantel in Schistosoma mansoni infected mice.
MedLine Citation:
PMID:  9257977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non steroidal anti-inflammatory drugs (NSAIDs) (tiaprofenic acid and piroxicam have been used alone and as adjuvants to praziquantel in treating hepatic granuloma in Schistosoma mansoni infected mice. Granuloma diameter, histamine metabolism, cyclic AMP and PGE2 levels have been measured at the end of treatment. Tiaprofenic acid effectively reduced the size of hepatic granuloma, significantly increased histamine forming capacity, CAMP level and significantly decreased plasma PGE2 level. Piroxicam had no significant effect on granuloma size, significantly decreased histamine forming capacity, CAMP and PGE2 levels. The combined therapy of either of the drugs with praziquantel did not result in an additive effect.
Authors:
I H Hegazy; S H Nassar; S M Moussa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the Egyptian Society of Parasitology     Volume:  27     ISSN:  1110-0583     ISO Abbreviation:  J Egypt Soc Parasitol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-29     Completed Date:  1997-09-29     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  8102141     Medline TA:  J Egypt Soc Parasitol     Country:  EGYPT    
Other Details:
Languages:  eng     Pagination:  397-404     Citation Subset:  IM    
Affiliation:
Department of Parasitology, Faculty of Medicine, University of Alexandria, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Cyclic AMP / metabolism
Dinoprostone / blood
Drug Therapy, Combination
Gastric Mucosa / drug effects,  physiopathology
Granuloma / drug therapy,  pathology
Histamine Release / drug effects
Liver / drug effects,  metabolism
Liver Diseases / drug therapy,  pathology
Mice
Piroxicam / therapeutic use*
Praziquantel / therapeutic use*
Propionates / therapeutic use*
Schistosomiasis mansoni / drug therapy*
Schistosomicides / therapeutic use*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Propionates; 0/Schistosomicides; 33005-95-7/tiaprofenic acid; 363-24-6/Dinoprostone; 36322-90-4/Piroxicam; 55268-74-1/Praziquantel; 60-92-4/Cyclic AMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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