Document Detail

Comparative effect of Neospora caninum infection in BALB/c mice at three different gestation periods.
MedLine Citation:
PMID:  17304808     Owner:  NLM     Status:  MEDLINE    
Neospora caninum has been recognized as a major cause of infectious bovine abortion worldwide. In the present study, the effect of N. caninum infection in mice at the 3 gestation periods (first, second, and third period) was investigated. In dams, tissue distribution of N. caninum was evaluated by nested polymerase chain reaction. In the progeny, fetal mortality, stillbirth, litter size, neonatal mortality/morbidity, vertical transmission, and parasite burden in neonatal tissues were evaluated. Pregnant BALB/c mice were infected subcutaneously with 2 x 10(6) NC-1 tachyzoites on days 0, 7, or 14 of gestation. Dams from each group were sequentially killed during gestation and postpartum (PP). Pups were killed on days 1 and 7 PP. Infection on day 0 of gestation produced a high vertical transmission rate, although no changes in fetal mortality, stillbirth, and littermate size were observed. The highest level of vertical transmission, together with an increase in fetal mortality and stillbirth and a decrease in litter size, were observed when infection was done on day 7 of gestation. Finally, infection on day 14 of gestation produced the lowest vertical transmission. Furthermore, infection at any time during gestation compromised the postnatal development of pups, because neonates from infected dams showed less body weight and a delay in the hair development.
Inmaculada C López-Pérez; Verónica Risco-Castillo; Esther Collantes-Fernández; Luis Miguel Ortega-Mora
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of parasitology     Volume:  92     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2007-02-19     Completed Date:  2007-03-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1286-91     Citation Subset:  IM    
Grupo SALUVET, Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
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MeSH Terms
Animals, Newborn
Brain / parasitology
Coccidiosis / parasitology,  transmission,  veterinary*
DNA, Protozoan / isolation & purification
Disease Models, Animal
Fetal Death / parasitology,  veterinary
Infectious Disease Transmission, Vertical / statistics & numerical data,  veterinary
Litter Size
Lung / parasitology
Mammary Glands, Animal / parasitology
Mice, Inbred BALB C
Milk / parasitology
Neospora* / genetics,  isolation & purification
Polymerase Chain Reaction / veterinary
Pregnancy Complications, Parasitic / parasitology,  veterinary*
Pregnancy Outcome / veterinary
Random Allocation
Stillbirth / veterinary
Time Factors
Reg. No./Substance:
0/DNA, Protozoan

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