Document Detail

Comparative double-blind study of flupenthixol decanoate and fluphenazine decanoate in the treatment of patients relapsing in a schizophrenic symptomatology.
MedLine Citation:
PMID:  6349256     Owner:  NLM     Status:  MEDLINE    
Thirty-two chronic schizophrenics who had relapsed entered a double-blind randomised study and were followed-up for 2 years with the intention of measuring any difference in therapeutic effect and side effects between flupenthixol decanoate and fluphenazine decanoate. No differences could be seen as regards the global effect or the effect on the schizophrenic symptomatology during the first 6 months. After 1 year of treatment flupenthixol decanoate showed a trend towards a better effect on schizophrenic symptomatology. A corresponding result was seen for the depressive symptoms. There were no differences in the appearance of side effects. The need for additional neuroleptics in the initial phase seemed to be identical for both drugs. A possible slow antipsychotic effect with flupenthixol decanoate is probably due to the administered dose being somewhat low (in the present study approximately 31 mg flupenthixol corresponding to 27 mg fluphenazine). This suggests that flupenthixol should have been given in a somewhat higher dose (25 mg fluphenazine decanoate corresponding to 40 mg flupenthixol decanoate).
B Wistedt; J Ranta
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  67     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-09-23     Completed Date:  1983-09-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  378-88     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Clinical Trials as Topic
Depression / drug therapy
Double-Blind Method
Flupenthixol / adverse effects,  analogs & derivatives,  therapeutic use*
Fluphenazine / adverse effects,  analogs & derivatives*,  therapeutic use
Middle Aged
Random Allocation
Schizophrenia / drug therapy*
Thioxanthenes / therapeutic use*
Time Factors
Reg. No./Substance:
0/Thioxanthenes; 2709-56-0/Flupenthixol; 30909-51-4/flupenthixol decanoate; 5002-47-1/fluphenazine depot; 69-23-8/Fluphenazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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