Document Detail


Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain.
MedLine Citation:
PMID:  8846397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution of amylin receptors (125I-labelled rat amylin) in brains of rat and monkey were mapped and compared with the distribution of receptors for calcitonin (CT) (125I-labelled salmon CT) and calcitonin gene related peptide (CGRP) (rat, 125I-labelled rat CGRP alpha; monkey, 125I-labelled human CGRP alpha. In rat, amylin receptors were discretely distributed with the highest receptor densities found in mid-caudal accumbens nucleus, parts of the bed nucleus of the stria terminalis, amygdala, and hypothalamus. Moderate to high densities of binding also occurred in the area postrema, subfornical organ, vascular organ of the lamina terminalis, locus ceruleus, dorsal raphe, and caudal solitary tract nucleus. In monkey, the distribution of amylin binding sites was similar, although the highest densities of receptors were in the hypothalamus, with relatively fewer sites present in the accumbens nucleus. In rat, the distribution of amylin receptors formed a subset of the receptor distributions for 125I-labelled salmon CT and 125I-labelled rat CGRP alpha. In contrast, in monkey, although the amylin receptors again formed a subset of the binding sites identified with 125I-labelled salmon CT, there was very little overlap with the pattern of CGRP receptor distribution. This suggests that the specificity profile of amylin receptors in primates differs from that of amylin receptors in the rat, with CGRP alpha having relatively lower affinity for the primate amylin receptors.
Authors:
G Christopoulos; G Paxinos; X F Huang; K Beaumont; A W Toga; P M Sexton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  73     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1037-41     Citation Subset:  IM    
Affiliation:
St. Vincent's Institute of Medical Research, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry*
Macaca mulatta
Male
Rats
Rats, Sprague-Dawley
Receptors, Calcitonin / analysis*
Receptors, Calcitonin Gene-Related Peptide / analysis*
Receptors, Peptide / analysis*
Species Specificity
Grant Support
ID/Acronym/Agency:
P20 MH/DA 52176/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Calcitonin; 0/Receptors, Calcitonin Gene-Related Peptide; 0/Receptors, Peptide; 0/amylin receptor

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