Document Detail


Comparative disposition kinetics of albendazole in sheep following oral and intraruminal administration.
MedLine Citation:
PMID:  10066128     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pharmacokinetics of albendazole was studied in sheep following single oral and intraruminal administration at nematocidal dose rates. The disposition curves of its metabolites indicated increased uptake of the drug in sheep following intraruminal as compared to oral dosing (p < 0.05). The increased bioavailability of benzimidazole anthelmintics given by the intraruminal route could be exploited for optimizing the use of anthelmintic for sustained parasite control in small ruminants.
Authors:
C P Swarnkar; P K Sanyal; D Singh; F A Khan; P S Bhagwan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Veterinary research communications     Volume:  22     ISSN:  0165-7380     ISO Abbreviation:  Vet. Res. Commun.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-05-04     Completed Date:  1999-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100520     Medline TA:  Vet Res Commun     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  545-51     Citation Subset:  IM    
Affiliation:
Central Sheep and Wool Research Institute, Avikanagar, Rajasthan, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Albendazole / administration & dosage,  blood,  pharmacokinetics*
Animals
Anthelmintics / administration & dosage,  blood,  pharmacokinetics*
Area Under Curve
Biological Availability
Chromatography, High Pressure Liquid / veterinary
Feces / parasitology
Half-Life
Regression Analysis
Rumen / metabolism*
Sheep / metabolism*
Chemical
Reg. No./Substance:
0/Anthelmintics; 54965-21-8/Albendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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