Document Detail

Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells.
MedLine Citation:
PMID:  20358977     Owner:  NLM     Status:  MEDLINE    
The increased applications of nanoparticles in a wide range of industrial fields raise the concern about their potential toxicity to human. The aim of this study was to assess and compare the toxicity of four different oxide nanoparticles (Al2O3, CeO2, TiO2 and ZnO) to human lung epithelial cells, A549 carcinoma cells and L-132 normal cells, in vitro. We focused on the toxicological effects of the present nanoparticles on cell proliferation, cell viability, membrane integrity and oxidative stress. The long-term cytotoxicity of nanoparticles was also evaluated by employing the clonogenic assay. Among four nanoparticles tested, ZnO exhibited the highest cytotoxicity in terms of cell proliferation, cell viability, membrane integrity and colony formation in both cell lines. Al2O3, CeO2 and TiO2 showed little adverse effects on cell proliferation and cell viability. However, TiO2 induced oxidative stress in a concentration- and time-dependent manner. CeO2 caused membrane damage and inhibited colony formation in long-term, but with different degree depending on cell lines. Al2O3 seems to be less toxic than the other nanoparticles even after long time exposure. These results highlight the need for caution during manufacturing process of nanomaterials as well as further investigation on the toxicity mechanism.
In-Sun Kim; Miri Baek; Soo-Jin Choi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  10     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-02     Completed Date:  2010-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3453-8     Citation Subset:  IM    
Department of Food Science and Technology, Seoul Women's University, Seoul 139-774, Korea.
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MeSH Terms
Aluminum Oxide / toxicity*
Apoptosis / drug effects
Biocompatible Materials / toxicity
Cell Proliferation / drug effects
Cell Survival / drug effects
Cells, Cultured
Cerium / toxicity*
Dose-Response Relationship, Drug
Epithelial Cells / cytology,  drug effects*,  physiology*
Materials Testing
Nanoparticles / toxicity*
Titanium / toxicity*
Zinc Oxide / toxicity*
Reg. No./Substance:
0/Biocompatible Materials; 1306-38-3/ceric oxide; 1314-13-2/Zinc Oxide; 1344-28-1/Aluminum Oxide; 13463-67-7/titanium dioxide; 7440-32-6/Titanium; 7440-45-1/Cerium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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