Document Detail

Comparative cytologic yield and quality of three Pap smear instruments.
MedLine Citation:
PMID:  8349063     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Various sampling techniques of the cervix have established false negative rates ranging from 18% to 45%. A number of studies suggest that this false negative rate can be reduced by sampling techniques that are associated with higher yields of endocervical cells. METHOD: This study enrolled 301 women, each of whom had a Pap smear obtained using three different sampling instruments (a cervical brush, a plastic spatula, and a cotton swab) in random order. RESULTS: The cervical brush yielded a better endocervical sample than either of the other instruments (P < .001), and there was no difference between the swab and spatula. In addition, the recovery of endocervical cells increased with each additional sample taken, regardless of instrument used (P < .001), although the difference in yield between the second and third samples was not significant. CONCLUSIONS: To enhance the yield of endocervical cells in Pap smear sampling, consideration should be given to using the cervical brush routinely as a sampling instrument and to taking more than one sample per screening.
W L Toffler; C K Pluedeman; A E Sinclair; K M Ireland; B J Byrne
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Family medicine     Volume:  25     ISSN:  0742-3225     ISO Abbreviation:  Fam Med     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-15     Completed Date:  1993-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306464     Medline TA:  Fam Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-7     Citation Subset:  IM    
Department of Family Medicine, Oregon Health Sciences University, Portland.
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MeSH Terms
False Negative Reactions
Middle Aged
Vaginal Smears / instrumentation*,  standards

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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