| Comparative controlled trial of low-dose weekly methotrexate versus azathioprine in rheumatoid arthritis: 3-year prospective study. | |
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MedLine Citation:
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PMID: 2182169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-three patients with rheumatoid arthritis who required immunosuppressive therapy were commenced in a randomized trial comparing azathioprine to weekly oral pulse methotrexate. After an initial 24-week period, both groups had significantly improved from baseline measures of pain and functional capacity and there were no significant differences in clinical outcomes between the two groups. Laboratory variables of disease activity showed a significant improvement in haemoglobin and ESR in the methotrexate group. Subsequently, the patients were followed for up to 3 years. After one year, more than half of the patients in both groups had discontinued therapy due to inefficacy or adverse events. Adverse effects were more frequent in the patients treated with methotrexate, but withdrawal rates were similar in both groups. From these data, the probability of a patient continuing therapy with either agent for greater than 18 months is low. |
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Authors:
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M H Arnold; J O'Callaghan; M McCredie; E M Beller; D E Kelly; P M Brooks |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of rheumatology Volume: 29 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-17 Completed Date: 1990-05-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 120-5 Citation Subset: AIM; IM |
Affiliation:
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Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St. Leonards, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Activities of Daily Living Adult Aged Arthritis, Rheumatoid / blood, drug therapy*, physiopathology Azathioprine / administration & dosage, adverse effects, therapeutic use* Blood Chemical Analysis Blood Sedimentation Clinical Trials as Topic Female Humans Male Methotrexate / administration & dosage, adverse effects, therapeutic use* Middle Aged Movement Pain Measurement Prospective Studies Random Allocation |
| Chemical | |
Reg. No./Substance:
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446-86-6/Azathioprine; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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