Document Detail

Comparative controlled trial of low-dose weekly methotrexate versus azathioprine in rheumatoid arthritis: 3-year prospective study.
MedLine Citation:
PMID:  2182169     Owner:  NLM     Status:  MEDLINE    
Fifty-three patients with rheumatoid arthritis who required immunosuppressive therapy were commenced in a randomized trial comparing azathioprine to weekly oral pulse methotrexate. After an initial 24-week period, both groups had significantly improved from baseline measures of pain and functional capacity and there were no significant differences in clinical outcomes between the two groups. Laboratory variables of disease activity showed a significant improvement in haemoglobin and ESR in the methotrexate group. Subsequently, the patients were followed for up to 3 years. After one year, more than half of the patients in both groups had discontinued therapy due to inefficacy or adverse events. Adverse effects were more frequent in the patients treated with methotrexate, but withdrawal rates were similar in both groups. From these data, the probability of a patient continuing therapy with either agent for greater than 18 months is low.
M H Arnold; J O'Callaghan; M McCredie; E M Beller; D E Kelly; P M Brooks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of rheumatology     Volume:  29     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-17     Completed Date:  1990-05-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  AIM; IM    
Florance and Cope Professorial Department of Rheumatology, Royal North Shore Hospital, St. Leonards, NSW, Australia.
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MeSH Terms
Activities of Daily Living
Arthritis, Rheumatoid / blood,  drug therapy*,  physiopathology
Azathioprine / administration & dosage,  adverse effects,  therapeutic use*
Blood Chemical Analysis
Blood Sedimentation
Clinical Trials as Topic
Methotrexate / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Pain Measurement
Prospective Studies
Random Allocation
Reg. No./Substance:
446-86-6/Azathioprine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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