Document Detail


Comparative clinical trial of epsilon amino-caproic acid and tranexamic acid in the prevention of early recurrence of subarachnoid haemorrhage.
MedLine Citation:
PMID:  7031186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparative controlled clinical trial of epsilon aminocaproic acid (EACA), 36 g/day and tranexamic acid (TEA), 6 g/day, was undertaken to assess their effectiveness in reducing early recurrence of subarachnoid haemorrhage (SAH). Of 90 patients treated with EACA recurrent haemorrhage was seen in 8% of these patients and 7% of the patients developed delayed ischaemic deficit. The total pre-operative mortality in EACA-group was 11%. Of 61 patients treated with TEA, 10% had recurrent haemorrhage and delayed ischaemic deficit occurred in 5% of the patients. The total pre-operative mortality in TEA-group was 11%. No difference was found between the effectiveness and side-effects of these drugs.
Authors:
U M Chowdhary; K Sayed
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  44     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  810-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
6-Aminocaproic Acid / adverse effects,  therapeutic use*
Adolescent
Adult
Aminocaproic Acids / therapeutic use*
Clinical Trials as Topic
Cyclohexanecarboxylic Acids / therapeutic use*
Female
Humans
Middle Aged
Recurrence
Subarachnoid Hemorrhage / mortality,  prevention & control*
Tranexamic Acid / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Aminocaproic Acids; 0/Cyclohexanecarboxylic Acids; 1197-18-8/Tranexamic Acid; 60-32-2/6-Aminocaproic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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