| Comparative chromosome examination of AKR mouse lymphoma after its i.p. transplantation with thymus- or spleen-derived lymphoma cells into hybrid mice. | |
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MedLine Citation:
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PMID: 3808125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A spontaneous AKR female mouse lymphoma was transplanted with its thymus cell suspension (10(6) cells i.p.) into AKR female mice. Lymph node cell suspension derived from one of the leukemic mice was injected (10(6) cells i.p.) into AKR females. The lymphoma cells "homing" to the thymus of one of the AKR females were suspended in Parker solution and 5 X 10(6) cells were given i.p. 5 (C3H X AKR) F3 hybrid mice (group 1). The lymphoma cells "homing" to the spleen of the same AKR female were also suspended, and 5 X 10(6) cells were injected i.p. into 5 (C3H X AKR) F3 hybrids (group 2). Chromosomes were prepared from the thymus and the spleen of two mice in both groups. The karyotypes derived from the hybrids of group 1 were compared to that of the group 2. It was found that the lymphoma cells "homing" to the thymus could be characterized by the trisomy of chromosome 15, while the lymphoma cells "homing" to the spleen had primarily the trisomy of chromosome 18. The results indicate that the thymus manifestation of the spontaneous AKR lymphoma is heterogeneous, and it contains at least two major subpopulations of the lymphoma cells. |
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Authors:
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A Selypes; R Lorencz; G Berencsi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neoplasma Volume: 33 ISSN: 0028-2685 ISO Abbreviation: Neoplasma Publication Date: 1986 |
Date Detail:
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Created Date: 1987-03-11 Completed Date: 1987-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377266 Medline TA: Neoplasma Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 707-11 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Karyotyping Lymph Nodes / pathology Lymphoma / genetics* Mice Neoplasm Transplantation Spleen / pathology* Thymus Gland / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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