Document Detail

Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids.
MedLine Citation:
PMID:  10680659     Owner:  NLM     Status:  MEDLINE    
Three mule deer and 4 mule deer/white-tailed deer hybrids were immobilized in a crossover study with carfentanil (10 microg/kg) + xylazine (0.3 mg/kg) (CX), and medetomidine (100 microg/kg) + ketamine (2.5 mg/kg) (MK). The deer were maintained in left lateral recumbency for 1 h with each combination. Deer were immobilized with MK in 230+/-68 s (mean +/- SD) and with CX in 282+/-83 seconds. Systolic, mean and diastolic arterial pressure were significantly higher with MK. Heart rate, PaO2, PaCO2, pH, and base excess were not significantly different between treatments. Base excess and pH increased significantly over time with both treatments. Both treatments produced hypoventilation (PaCO2 > 50 mm Hg) and hypoxemia (PaO2 < 60 mm Hg). PaO2 increased significantly over time with CX. Body temperature was significantly (P<0.05) higher with CX compared to MK. Ventricular premature contractions, atrial premature contractions, and a junctional escape rhythm were noted during CX immobilization. No arrhythmias were noted during MK immobilization. Quality of immobilization was superior with MK, with no observed movement present for the 60 min of immobilization. Movement of the head and limbs occurred in 4 animals immobilized with CX. The major complication observed with both of these treatments was hypoxemia, and supplemental inspired oxygen is recommended during immobilization. Hyperthermia can further complicate immobilization with CX, reinforcing the need for supplemental oxygen.
N A Caulkett; P H Cribb; J C Haigh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire     Volume:  64     ISSN:  0830-9000     ISO Abbreviation:  Can. J. Vet. Res.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-09     Completed Date:  2000-03-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8607793     Medline TA:  Can J Vet Res     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
Department of Veterinary Anesthesiology, Radiology and Surgery, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon,
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MeSH Terms
Adrenergic alpha-Agonists / administration & dosage,  adverse effects,  pharmacology*
Analgesics, Opioid / administration & dosage,  adverse effects,  pharmacology*
Anesthetics, Dissociative / administration & dosage,  adverse effects,  pharmacology*
Animal Welfare
Animals, Wild
Anoxia / chemically induced,  veterinary
Fentanyl / administration & dosage,  adverse effects,  analogs & derivatives*,  pharmacology
Fever / chemically induced,  veterinary
Heart Rate / drug effects
Hypnotics and Sedatives / adverse effects,  pharmacology*
Ketamine / administration & dosage,  adverse effects,  pharmacology*
Medetomidine / administration & dosage,  adverse effects,  pharmacology*
Respiration / drug effects
Xylazine / administration & dosage,  adverse effects,  pharmacology*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Analgesics, Opioid; 0/Anesthetics, Dissociative; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 59708-52-0/carfentanil; 6740-88-1/Ketamine; 7361-61-7/Xylazine; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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