Document Detail

Comparative biokinetics of radiocarbon ingested as compounds or foods in rats.
MedLine Citation:
PMID:  20938237     Owner:  NLM     Status:  MEDLINE    
The biokinetics of radiocarbon (¹⁴C) in rats continuously ingested in the forms of amino acids (glycine and leucine) or as foods (wheat and rapeseed) were examined and compared with each other. The differences in the biokinetics between ¹⁴C-amino acids and ¹⁴C-foods were observed in the excretion of ¹⁴C in feces and in the incorporation and retention of ¹⁴C in the rat tissues. At the 10 week of continuous ingestion of ¹⁴C-amino acids, the integrated activities of ¹⁴C in all the tissues were within 5% of the ingested activity. The integrated activities in each tissue coming from ¹⁴C-food ingestion were higher by a factor of more than 2 compared to those coming from ¹⁴C-amino acid ingestion. Radiation dose rates estimated at the 10 week showed that the dose rates to the individual tissues coming from ¹⁴C-food ingestion were 2-5 times higher than those coming from ¹⁴C-amino acid ingestion. The difference in the dose rate between ¹⁴C-amino acid and ¹⁴C-food was more significant in adipose tissue by a factor of 7-30.
Hiroshi Takeda; Shoichi Fuma; Kei Yanagisawa; Nobuyoshi Ishii; Anca Melintescu; Dan Galeriu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Health physics     Volume:  99     ISSN:  1538-5159     ISO Abbreviation:  Health Phys     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985093R     Medline TA:  Health Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  668-73     Citation Subset:  IM    
Research Center for Radiation Protection, National Institute of Radiological Sciences, 9-1 Anagawa-4-chome, Inage-ku, Chiba-shi 263-8555, Japan.
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MeSH Terms
Amino Acids / pharmacokinetics*
Animal Feed*
Carbohydrate Metabolism
Carbon Radioisotopes / pharmacokinetics
Fatty Acids / metabolism,  pharmacokinetics
Rats, Wistar
Reg. No./Substance:
0/Amino Acids; 0/Carbon Radioisotopes; 0/Fatty Acids

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