Document Detail


Comparative bioavailability evaluation of erythromycin base and its salts and esters. I. Erythromycin estolate capsules versus enteric-coated erythromycin base tablets.
MedLine Citation:
PMID:  7430412     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A randomized crossover study in 16 healthy volunteers given multiple doses of erythromycin base enteric-coated tablets or erythromycin estolate capsules revealed essentially no difference in the resultant plasma concentration of bioactive erythromycin. This similarity in bioactivity persisted despite the fact that total eryghromycin levels (bioactive erythromycin base plus bioinactive erythromycin propionate) were at least three times higher after administration of the estolate than after administration of the base.
Authors:
A R DiSanto; K Y Tserng; D J Chodos; K A DeSante; K S Albert; J G Wagner
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  20     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  437-43     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Availability
Capsules
Erythromycin / administration & dosage,  analogs & derivatives*,  metabolism*
Erythromycin Estolate / administration & dosage,  metabolism*
Female
Humans
Male
Random Allocation
Tablets, Enteric-Coated
Time Factors
Chemical
Reg. No./Substance:
0/Capsules; 0/Tablets, Enteric-Coated; 114-07-8/Erythromycin; 3521-62-8/Erythromycin Estolate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetic interpretation of plasma cortisol and cortisone concentrations following a signle or...
Next Document:  Biochemical and histological effects of intermittent carbon monoxide exposure in cynomolgus monkeys ...