| Comparative behavioural effects of benzodiazepine and non-benzodiazepine anxiolytics in rhesus monkeys. | |
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MedLine Citation:
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PMID: 10373237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quantitative behavioural assessment of benzodiazepines (chlordiazepoxide, diazepam and lorazepam) and non-benzodiazepines (buspirone) anxiolytics were investigated in unrestrained rhesus monkeys (Macaca mulatta) living in social colonies. The different behaviour, categorised as social, solitary and abnormal were video recorded and analysed. Chlordiazepoxide (2.5-5 mg kg-1, p.o.), diazepam (2.5-5 mg kg-1, p.o.) and lorazepam (0.5-1 mg kg-1, p.o.) induced dose-dependent significant changes in certain social and solitary behavioural responses. Thus increases in social grooming, approach, contact, self grooming, feeding and resting with eyes open and decreased aggressiveness and vigilance. On the other hand buspirone (5-10 mg kg-1, p.o.) produced no significant alteration in social and solitary behavioural patterns. On the basis of the above findings the social and solitary behaviour protocol in non-human primates can be a useful tool for studying the effect of a new anxiolytic compound before clinical trial. |
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Authors:
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R Kumar; G Palit; J R Singh; B N Dhawan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 39 ISSN: 1043-6618 ISO Abbreviation: Pharmacol. Res. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-08-05 Completed Date: 1999-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 437-44 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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Primate Behaviour Laboratory, Division of Pharmacology, Lucknow, 226 001, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents / pharmacology* Behavior, Animal / drug effects* Buspirone / pharmacology Chlordiazepoxide / pharmacology Diazepam / pharmacology Dose-Response Relationship, Drug Female Macaca mulatta Male Social Behavior |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 36505-84-7/Buspirone; 439-14-5/Diazepam; 58-25-3/Chlordiazepoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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