Document Detail

Comparative behavioral effects between synthetic 2,4,5-trimethylthiazoline (TMT) and the odor of natural fox (Vulpes vulpes) feces in mice.
MedLine Citation:
PMID:  17907837     Owner:  NLM     Status:  MEDLINE    
Synthetic 2,4,5-trimethylthiazoline (TMT)--a component of red fox (Vulpes vulpes) feces--is frequently used to induce unconditioned fear in rodents. Surprisingly, direct comparison between TMT and natural fox feces odor is almost nonexistent. In this study, Experiment 1 compared the avoidance in relation to TMT concentration, natural fox feces, and gender of fox and mice. Results show that the avoidance is (a) higher with either pure or 50% TMT as compared to natural fox feces, whereas the difference is slight with 10% TMT, and (b) significantly higher for the female mouse group compared to the male mouse group with TMT as well as natural fox feces. In addition, no clear difference in effect was observed between male and female fox feces. Experiment 2 compared behavioral parameters recorded as an index of fear and anxiety, general activity, and avoidance in elevated plus-maze and open-field chamber between 10% TMT and natural fox feces in relation to the estrus cycle of the mice. Results show no cycle period effect--except for the avoidance parameter "distance to odorant"--and no different effects between 10% TMT and natural fox feces except for freezing.
Gaelle Buron; Romain Hacquemand; Gregory Pourie; Annie Lucarz; Laurence Jacquot; Gerard Brand
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  121     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-02     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1063-72     Citation Subset:  IM    
Copyright Information:
(PsycINFO Database Record (c) 2007 APA, all rights reserved).
Laboratoire de Neurosciences, Universite de Franche-Comte, Besancon, France.
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MeSH Terms
Anxiety / psychology
Behavior, Animal / drug effects*
Estrous Cycle / physiology
Feces / chemistry*
Foxes / metabolism*
Motor Activity / drug effects
Sex Characteristics
Stress, Psychological / psychology
Thiazoles / pharmacology*
Vagina / physiology
Reg. No./Substance:
0/2,4,5 trimethylthiazoline; 0/Thiazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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