| Comparative assessment of cylacillin and ampicillin by experimental therapy and by serum level determinations in rats and mice. | |
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MedLine Citation:
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PMID: 1253633 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Therapy of chronic E. coli pyelonephritis in rats was equally effective with cyclacillin and oral ampicillin, whereas intramuscular ampicillin had a significantly higher therapeutic activity than oral cyclacillin. Serum concentrations in rats and mice were consistently higher with cyclacillin than with ampicillin and showed great variations depending on the animal species. It was concluded that there is a good correlation between in vivo and in vitro activity of both antibiotics, provided that the serum levels are taken into consideration. On this basis it may be predicted that a man cyclacillin will exhibit lower therapeutic activity in gram-negative infections than ampicillin. |
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Authors:
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H Freiesleben; K Sack |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 22 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1976 |
Date Detail:
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Created Date: 1976-05-10 Completed Date: 1976-05-10 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 75-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Ampicillin / administration & dosage, blood, therapeutic use* Animals Chronic Disease Dose-Response Relationship, Drug Drug Evaluation, Preclinical Female Injections, Intramuscular Penicillins / therapeutic use* Pyelonephritis / drug therapy* Rats |
| Chemical | |
Reg. No./Substance:
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0/Penicillins; 69-53-4/Ampicillin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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