| Comparative aspects of osteosarcoma. Dog versus man. | |
| | |
MedLine Citation:
|
PMID: 1884536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Canine osteosarcoma bears striking resemblance to osteosarcoma in humans. Similarities include the following: male sex predilection, large patient size, 75% or more affecting the appendicular site, metaphyseal location, generally unknown etiology, less than 10% of patients have documented metastasis at presentation, over 90% of tumors show high-grade histology, 75% of tumors show aneuploidy, the metastatic rate is 80% or more with amputation alone, the lung is the most common site of metastasis, and there is improved survival with adjuvant chemotherapy. The major differences are age of onset, with dogs being affected in middle age; greater frequency in the dog, with over 8000 new cases per year; and time to metastasis being faster in the dog than man. Canine osteosarcoma is a readily available and highly comparable spontaneously occurring cancer that should be useful in a better understanding of the same disease in humans. |
| | |
Authors:
|
S J Withrow; B E Powers; R C Straw; R M Wilkins |
Related Documents
:
|
17696856 - Efficacy of temozolomide or dacarbazine in combination with an anthracycline for rescue... 19499296 - Effect of increases in tumor volume after neoadjuvant chemotherapy on the outcome of st... 17909926 - Extraskeletal osteosarcoma in japan: multiinstitutional study of 20 patients from the j... 19379216 - Survival analysis of one versus two treatments of local delivery cisplatin in a biodegr... 1571116 - Prognostic factors in the recurrence of stage i and ii squamous cell cancer of the oral... 8996906 - The role of radiotherapy in thymomas. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Clinical orthopaedics and related research Volume: - ISSN: 0009-921X ISO Abbreviation: Clin. Orthop. Relat. Res. Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1991-10-10 Completed Date: 1991-10-10 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0075674 Medline TA: Clin Orthop Relat Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 159-68 Citation Subset: AIM; IM |
Affiliation:
|
Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Department of Clinical Sciences, Fort Collins 80523. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Animals Bone Neoplasms / epidemiology*, mortality, pathology Disease Models, Animal Dogs* Female Humans Male Osteosarcoma / epidemiology*, mortality, pathology Sex Factors Survival Rate |
| Grant Support | |
ID/Acronym/Agency:
|
1 P01 CA-29582/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent ...
Next Document: Flow cytometric studies of human osteosarcoma.