Document Detail


Comparative antibacterial activity of the new cephalosporin cefcanel against anaerobic bacteria.
MedLine Citation:
PMID:  2548866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of cefcanel against anaerobic cocci, Clostridium perfringens, Bacteroides fragilis, Bacteroides spp. and fusobacteria was determined by the agar dilution method and compared with the activity of cefaclor, cephalexin, cefadroxil, phenoxymethylpenicillin and ampicillin. Cefcanel showed good activity against Clostridium perfringens, Bacteroides spp. and fusobacteria (MIC90 = 1-4 mg/l). Against anaerobic cocci its MIC90 value was 16 mg/l, and against Bacteroides fragilis, 32 mg/l. Cefcanel has an antibacterial activity that warrants investigation in clinical trials.
Authors:
C E Nord; A Lindmark; I Persson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  8     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-06     Completed Date:  1989-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  550-1     Citation Subset:  IM    
Affiliation:
Department of Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Ampicillin / pharmacology
Bacteria, Anaerobic / drug effects*
Bacteroides / drug effects
Bacteroides fragilis / drug effects
Cefaclor / pharmacology
Cefadroxil / pharmacology
Cefazolin / analogs & derivatives*,  pharmacology
Cephalexin / pharmacology
Cephalosporins / pharmacology*
Clostridium perfringens / drug effects
Fusobacterium / drug effects
Humans
Microbial Sensitivity Tests
Penicillin V / pharmacology
beta-Lactamases / biosynthesis
Chemical
Reg. No./Substance:
0/Cephalosporins; 15686-71-2/Cephalexin; 25953-19-9/Cefazolin; 41952-52-7/cefcanel; 50370-12-2/Cefadroxil; 53994-73-3/Cefaclor; 69-53-4/Ampicillin; 87-08-1/Penicillin V; EC 3.5.2.6/beta-Lactamases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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