| Comparative anatomy and phylogenetic distribution of the mammalian cecal appendix. | |
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MedLine Citation:
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PMID: 19678866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A recently improved understanding of gut immunity has merged with current thinking in biological and medical science, pointing to an apparent function of the mammalian cecal appendix as a safe-house for symbiotic gut microbes, preserving the flora during times of gastrointestinal infection in societies without modern medicine. This function is potentially a selective force for the evolution and maintenance of the appendix, and provides an impetus for reassessment of the evolution of the appendix. A comparative anatomical approach reveals three apparent morphotypes of the cecal appendix, as well as appendix-like structures in some species that lack a true cecal appendix. Cladistic analyses indicate that the appendix has evolved independently at least twice (at least once in diprotodont marsupials and at least once in Euarchontoglires), shows a highly significant (P < 0.0001) phylogenetic signal in its distribution, and has been maintained in mammalian evolution for 80 million years or longer. |
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Authors:
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H F Smith; R E Fisher; M L Everett; A D Thomas; R Randal Bollinger; W Parker |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-08-12 |
Journal Detail:
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Title: Journal of evolutionary biology Volume: 22 ISSN: 1420-9101 ISO Abbreviation: J. Evol. Biol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-22 Completed Date: 2009-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809954 Medline TA: J Evol Biol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1984-99 Citation Subset: IM |
Affiliation:
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Department of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, in Partnership with Arizona State University, Phoenix, AZ, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cecum / anatomy & histology*, microbiology Mammals / anatomy & histology*, classification* Phylogeny* |
| Grant Support | |
ID/Acronym/Agency:
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P30 DK34987/DK/NIDDK NIH HHS; R01 HL60232-03/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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