Document Detail


Comparative anatomy of mouse and human nail units.
MedLine Citation:
PMID:  23408541     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies of mice with hair defects have resulted in major contributions to the understanding of hair disorders. To use mouse models as a tool to study nail diseases, a basic understanding of the similarities and differences between the human and mouse nail unit is required. In this study we compare the human and mouse nail unit at the macroscopic and microscopic level and use immunohistochemistry to determine the keratin expression patterns in the mouse nail unit. Both species have a proximal nail fold, cuticle, nail matrix, nail bed, nail plate, and hyponychium. Distinguishing features are the shape of the nail and the presence of an extended hyponychium in the mouse. Expression patterns of most keratins are similar. These findings indicate that the mouse nail unit shares major characteristics with the human nail unit and overall represents a very similar structure, useful for the investigation of nail diseases and nail biology.
Authors:
Philip Fleckman; Karin Jaeger; Kathleen A Silva; John P Sundberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomical record (Hoboken, N.J. : 2007)     Volume:  296     ISSN:  1932-8494     ISO Abbreviation:  Anat Rec (Hoboken)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-14     Completed Date:  2013-07-29     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  101292775     Medline TA:  Anat Rec (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  521-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Anatomy, Comparative*
Animals
Biological Markers / analysis
Dissection
Female
Hoof and Claw / anatomy & histology*,  chemistry,  radiography,  ultrastructure
Humans
Immunohistochemistry
Keratins / analysis
Male
Mice
Mice, Inbred C57BL
Microscopy, Electron, Scanning
Nails / anatomy & histology*,  chemistry,  radiography,  ultrastructure
Posture
Species Specificity
X-Ray Microtomography
Grant Support
ID/Acronym/Agency:
AR047204/AR/NIAMS NIH HHS; AR054407/AR/NIAMS NIH HHS; AR056635/AR/NIAMS NIH HHS; AR49288/AR/NIAMS NIH HHS; CA34196/CA/NCI NIH HHS; OD010920/OD/NIH HHS; R01 AR049288/AR/NIAMS NIH HHS; R01 AR056635/AR/NIAMS NIH HHS; R13 OD010920/OD/NIH HHS; R21 AR054407/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 68238-35-7/Keratins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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