| Comparative analysis of spinal hemangioblastomas in sporadic disease and Von Hippel-Lindau syndrome. | |
| | |
MedLine Citation:
|
PMID: 20671381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The clinical differences were evaluated in spinal hemangioblastoma between patients with sporadic disease and patients with von Hippel-Lindau (VHL) syndrome. The distribution of hemangioblastomas in the central nervous system was investigated in 56 patients treated between 1988 and 2008 at the University of Tokyo Hospital. The characteristics of spinal hemangioblastomas were compared in 35 patients including 17 with sporadic disease and 18 with VHL syndrome treated between 1988 and 2008 at our hospital and three affiliated institutions. Spinal hemangioblastomas were much more prevalent in patients with VHL syndrome (88.2%) than in patients with sporadic disease (20.5%, p < 0.001). Spinal hemangioblastomas associated with VHL syndrome were diagnosed a decade earlier (p = 0.007) and were associated with less severe neurological symptoms than sporadic lesions (p = 0.004). Most patients with sporadic disease had a single lesion at the cervical or thoracic level, whereas patients with VHL syndrome had multiple lesions at all spinal levels (p = 0.04). Patients with sporadic disease exhibited significant improvement in postoperative neurological status (p = 0.02), whereas patients with VHL syndrome had no change in status (p = 1.00). Number of removed lesions (p = 0.03) and lower spinal cord lesions (p = 0.05) were associated with poor surgical outcome. Tumor recurrence was correlated with partial removal of lesions (p = 0.05). One third of patients with VHL syndrome developed new lesions every 2 years. The major finding of this study is that the incidence of spinal hemangioblastoma, distributed through all spinal levels, may be as high as 88% in patients with VHL syndrome, which is much greater than previously reported. |
| | |
Authors:
|
Keisuke Takai; Makoto Taniguchi; Hiroshi Takahashi; Masaaki Usui; Nobuhito Saito |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Neurologia medico-chirurgica Volume: 50 ISSN: 1349-8029 ISO Abbreviation: Neurol. Med. Chir. (Tokyo) Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-07-30 Completed Date: 2010-12-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0400775 Medline TA: Neurol Med Chir (Tokyo) Country: Japan |
Other Details:
|
Languages: eng Pagination: 560-7 Citation Subset: IM |
Affiliation:
|
Department of Neurosurgery, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan. takai-nsu@umin.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cross-Sectional Studies Female Follow-Up Studies Hemangioblastoma / diagnosis, epidemiology*, surgery Humans Japan Male Microsurgery Middle Aged Neurologic Examination Postoperative Complications / etiology Spinal Cord Neoplasms / diagnosis, epidemiology*, surgery Treatment Outcome Young Adult von Hippel-Lindau Disease / diagnosis, epidemiology*, surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuropsychological improvement in patients with cervical spondylotic myelopathy after posterior deco...
Next Document: Fusiform aneurysm associated with fenestration of the posterior communicating artery.