Document Detail

Comparative analysis of the mast cell density in normal oral mucosa, actinic cheilitis and lip squamous cell carcinoma.
MedLine Citation:
PMID:  18949288     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that the number of mast cells is increased in ultraviolet (UV) irradiated skin and in neoplasias. Actinic cheilitis (AC) is a lesion caused by excessive exposure to sunlight that can transform into lip squamous cell carcinoma. The aim of this study was to compare the number of mast cells in 4 groups: NOM = normal oral mucosa (n=6); MDAC = mild dysplasia in actinic cheilitis (n=13); SDAC = severe dysplasia in actinic cheilitis (n=13); and LSCC = lip squamous cell carcinoma (n=15). The sections were stained by histochemical technique of blue toluidine and visual counting was performed with the aid of a reticulum coupled to the microscope ocular. A calibrated observer performed the count in 5 fields by case at x400 magnification. The largest mean number of mast cells per group was observed in LSCC (40.1), followed by MDAC (30.5), SDAC (28.6) and NOM (12.2). There were significant differences between NOM and MDAC (p<0.05) and between NOM and LSCC (p<0.05). The increased density of mast cells observed in AC and in LSCC compared to NOM suggests a role for the mast cells in the development of these lesions.
Ana Paula Neutzling Gomes; Julia Elis Johann; Gabriela Gularte Lovato; Aline Marques Ferreira
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian dental journal     Volume:  19     ISSN:  1806-4760     ISO Abbreviation:  Braz Dent J     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-24     Completed Date:  2009-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214652     Medline TA:  Braz Dent J     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  D    
Department of Semiology and Clinics, Dental School, Federal University of Pelotas, Pelotas, RS, Brazil.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Cell Count
Cheilitis / pathology*
Coloring Agents / diagnostic use
Lip Neoplasms / pathology*
Mast Cells / pathology*
Mouth Mucosa / pathology*
Sunlight / adverse effects
Tolonium Chloride / diagnostic use
Reg. No./Substance:
0/Coloring Agents; 92-31-9/Tolonium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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