| Comparative analysis of the invasion-associated genes expression pattern in first trimester trophoblastic (HTR-8/SVneo) and JEG-3 choriocarcinoma cells. | |
| | |
MedLine Citation:
|
PMID: 22800585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Several cellular models of trophoblast have been proposed to understand their invasion. We had reported that JEG-3 and HTR-8/SVneo cells show differential invasive behavior in response to IL-11 treatment. So, the present study aims to compare the expression of invasion-associated molecules in these two cell lines by performing cDNA microarray followed by quantitative RT-PCR. We have observed that HTR-8/SVneo cells have significantly higher invasiveness than JEG-3 cells, which might be due to higher expression of proteases and signaling intermediates of JAK/STAT and MAPK signaling pathways. Like extravillous trophoblasts (EVTs), a higher expression of functionally significant proteases like MMP1, MMP2, MMP9, PLAU etc in HTR-8/SVneo cells, project them as a close mimic of EVTs under in vitro conditions. |
| | |
Authors:
|
P Suman; S K Gupta |
Related Documents
:
|
21255805 - The histone deacetylase inhibitor trichostatin a synergistically resensitizes a cisplat... 21551075 - Glioblastoma motility occurs in the absence of actin polymer. 21465485 - Overexpression of mir-210, a downstream target of hif1α, causes centrosome amplificati... 4755845 - Localization of the violet and yellow receptor cells in the crayfish retinula. 1282085 - Differentiation and dedifferentiation of the human monocytic leukemia cell line, u937. 7174735 - Human mutant cell lines with altered rna polymerase ii. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-14 |
Journal Detail:
|
Title: Placenta Volume: - ISSN: 1532-3102 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential loading methods for BMP-2 within injectable calcium phosphate cement.
Next Document: [Situation of common psychosomatic symptom in adolescent and its influence on 6 months later suicide...