Document Detail

Comparative analysis of the human type 1a and bovine type 1 papillomavirus genomes.
MedLine Citation:
PMID:  6302319     Owner:  NLM     Status:  MEDLINE    
The DNA sequences of the genomes of the bovine type 1 and human type 1a papillomaviruses were compared. The overall organization of both genomes is very similar. Three areas of maximal homology were found in the L1 and E1/E2 genes, and at the beginning of L2. The conservation of homologous amino acid sequences encoded in the open reading frames argues that these segments represent real genes or exons. Within these segments, however, only certain domains of the putative proteins are preferentially conserved. Two polypeptide chains show homologous arrangement of the cysteine residue clusters Cys-X-X-Cys, despite a lack of conservation of the rest of the amino acid sequence. A significant sequence divergence in a region where the three reading frames are open suggests that papillomavirus genomes have evolved not solely by accumulation of point mutations. Conserved sequences were also found in the noncoding region, and their possible involvement in regulation of viral gene expression is discussed.
O Danos; L W Engel; E Y Chen; M Yaniv; P M Howley
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of virology     Volume:  46     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-10     Completed Date:  1983-06-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  557-66     Citation Subset:  IM    
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MeSH Terms
Amino Acid Sequence
Base Sequence
Bovine papillomavirus 1 / genetics*
DNA, Viral
Genes, Regulator
Genes, Viral*
Papillomaviridae / genetics*
Repetitive Sequences, Nucleic Acid
Viral Proteins / genetics
Reg. No./Substance:
0/Codon; 0/DNA, Viral; 0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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