| Comparative analysis of the fusion efficiency elicited by the envelope glycoprotein V1-V5 regions derived from human immunodeficiency virus type 1 transmitted perinatally. | |
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MedLine Citation:
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PMID: 22956734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the properties of viruses preferentially establishing infection during perinatal transmission of human immunodeficiency virus type 1 (HIV-1) is critical for the development of effective measures to prevent transmission. A previous study demonstrated that the newly transmitted viruses (in infants) of chronically infected mother-infant pairs (MIPs) were fitter in terms of growth, which was imparted by their envelope (Env) glycoprotein V1-V5 regions, than those in the corresponding chronically infected mothers. In order to investigate whether the higher fitness of transmitted viruses was conferred by their higher entry efficiency directed by the V1-V5 regions during perinatal transmission, the fusogenicity of Env containing V1-V5 regions derived from transmitted and non-tranmsmitted viruses of five chronically infected MIPs and two acutely infected MIPs was analysed using two different cell-cell fusion assays. The results showed that, in one chronically infected MIP, a higher fusion efficiency was induced by the infant Env V1-V5 compared with that of the corresponding mother. Moreover, the V4-V5 regions played an important role in discriminating the transmitted and non-transmitted viruses in this pair. However, neither a consistent pattern nor significant differences in fusogenicity mediated by the V1-V5 regions between maternal and infant variants was observed in the other MIPs. This study suggests that there is no consistent and significant correlation between viral fitness selection and entry efficiency directed by the V1-V5 regions during perinatal transmission. Other factors such as the route and timing of transmission may also be involved. |
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Authors:
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Hongyan Guo; Levon G Abrahamyan; Chang Liu; Mackenzie Waltke; Yunqi Geng; Qimin Chen; Charles Wood; Xiaohong Kong |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2012-09-05 |
Journal Detail:
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Title: The Journal of general virology Volume: 93 ISSN: 1465-2099 ISO Abbreviation: J. Gen. Virol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-19 Completed Date: 2013-01-25 Revised Date: 2013-03-20 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: England |
Other Details:
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Languages: eng Pagination: 2635-45 Citation Subset: IM |
Affiliation:
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Laboratory of Medical Molecular Virology, School of Medicine, Nankai University, Tianjin, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acid Sequence Base Sequence DNA, Viral / genetics Female HIV Envelope Protein gp120 / genetics, physiology HIV Infections / transmission*, virology* HIV-1 / genetics, pathogenicity*, physiology* Humans Infant, Newborn Infectious Disease Transmission, Vertical* Male Molecular Sequence Data Peptide Fragments / genetics, physiology Pregnancy Pregnancy Complications, Infectious / virology* Sequence Homology, Amino Acid Viral Fusion Proteins / genetics, physiology Virus Internalization Young Adult env Gene Products, Human Immunodeficiency Virus / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA075903/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/HIV Envelope Protein gp120; 0/HIV envelope protein gp120 (135-148); 0/HIV envelope protein gp120 (305-321); 0/Peptide Fragments; 0/Viral Fusion Proteins; 0/env Gene Products, Human Immunodeficiency Virus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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