Document Detail


Comparative analysis of the fusion efficiency elicited by the envelope glycoprotein V1-V5 regions derived from human immunodeficiency virus type 1 transmitted perinatally.
MedLine Citation:
PMID:  22956734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Understanding the properties of viruses preferentially establishing infection during perinatal transmission of human immunodeficiency virus type 1 (HIV-1) is critical for the development of effective measures to prevent transmission. A previous study demonstrated that the newly transmitted viruses (in infants) of chronically infected mother-infant pairs (MIPs) were fitter in terms of growth, which was imparted by their envelope (Env) glycoprotein V1-V5 regions, than those in the corresponding chronically infected mothers. In order to investigate whether the higher fitness of transmitted viruses was conferred by their higher entry efficiency directed by the V1-V5 regions during perinatal transmission, the fusogenicity of Env containing V1-V5 regions derived from transmitted and non-tranmsmitted viruses of five chronically infected MIPs and two acutely infected MIPs was analysed using two different cell-cell fusion assays. The results showed that, in one chronically infected MIP, a higher fusion efficiency was induced by the infant Env V1-V5 compared with that of the corresponding mother. Moreover, the V4-V5 regions played an important role in discriminating the transmitted and non-transmitted viruses in this pair. However, neither a consistent pattern nor significant differences in fusogenicity mediated by the V1-V5 regions between maternal and infant variants was observed in the other MIPs. This study suggests that there is no consistent and significant correlation between viral fitness selection and entry efficiency directed by the V1-V5 regions during perinatal transmission. Other factors such as the route and timing of transmission may also be involved.
Authors:
Hongyan Guo; Levon G Abrahamyan; Chang Liu; Mackenzie Waltke; Yunqi Geng; Qimin Chen; Charles Wood; Xiaohong Kong
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-09-05
Journal Detail:
Title:  The Journal of general virology     Volume:  93     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-01-25     Revised Date:  2014-07-16    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2635-45     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Sequence
Base Sequence
DNA, Viral / genetics
Female
HIV Envelope Protein gp120 / genetics,  physiology
HIV Infections / transmission*,  virology*
HIV-1 / genetics,  pathogenicity*,  physiology*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Male
Molecular Sequence Data
Peptide Fragments / genetics,  physiology
Pregnancy
Pregnancy Complications, Infectious / virology*
Sequence Homology, Amino Acid
Viral Fusion Proteins / genetics,  physiology
Virus Internalization
Young Adult
env Gene Products, Human Immunodeficiency Virus / genetics,  physiology*
Grant Support
ID/Acronym/Agency:
R01 CA075903/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Viral; 0/HIV Envelope Protein gp120; 0/HIV envelope protein gp120 (135-148); 0/HIV envelope protein gp120 (305-321); 0/Peptide Fragments; 0/Viral Fusion Proteins; 0/env Gene Products, Human Immunodeficiency Virus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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