| Comparative analysis of the effects of rice and bread meals on bioavailability of itraconazole using NONMEM in healthy volunteers. | |
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MedLine Citation:
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PMID: 17053894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objectives of this retrospective study were to examine the relationship between the bioavailability of itraconazole and the type of food consumed and to determine the effects of food consumption on the pharmacokinetic parameters following a single oral dose of itraconazole in healthy volunteers. METHODS: The plasma itraconazole concentration-time data were pooled from four pharmacokinetic studies in 144 healthy subjects. Individual pharmacokinetic values were estimated as model-independent (AUC, C (max), and T (max)) and model-dependent (T (lag), K (a), K (cp), K (pc), K (el), and V (d)/F; two-compartment open model with lag time) parameters using the WinNonlin software program. We estimated the population characteristics of the food effects using NONMEM. RESULTS: The consumption of a bread meal before the administration of itraconazole caused a significant increase in its bioavailability, as well as increases in the peak plasma concentration and lag time for itraconazole absorption. On the contrary, consumption of a rice meal before the administration of itraconazole caused a significant decrease in its bioavailability. CONCLUSION: Therefore, although a dose of itraconazole is normally administered immediately after a meal to increase its bioavailability, this is not an effective strategy after a rice meal. |
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Authors:
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Hwi-yeol Yun; Min Sun Baek; In Sook Park; Bo Kyung Choi; Kwang-il Kwon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-10-20 |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 62 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-19 Completed Date: 2007-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 1033-9 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Chungnam National University, Daejeon 305-764, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Algorithms Analysis of Variance Antifungal Agents / administration & dosage, blood, pharmacokinetics Area Under Curve Biological Availability Bread* Capsules Chromatography, High Pressure Liquid / methods Cluster Analysis Cross-Over Studies Dose-Response Relationship, Drug Eating / physiology* Female Food-Drug Interactions Humans Itraconazole / administration & dosage, blood, pharmacokinetics* Male Oryza sativa* Retrospective Studies Software* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Capsules; 84625-61-6/Itraconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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