Document Detail


Comparative analysis of the distribution of segmented filamentous bacteria in humans, mice and chickens.
MedLine Citation:
PMID:  23151642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segmented filamentous bacteria (SFB) are indigenous gut commensal bacteria. They are commonly detected in the gastrointestinal tracts of both vertebrates and invertebrates. Despite the significant role they have in the modulation of the development of host immune systems, little information exists regarding the presence of SFB in humans. The aim of this study was to investigate the distribution and diversity of SFB in humans and to determine their phylogenetic relationships with their hosts. Gut contents from 251 humans, 92 mice and 72 chickens were collected for bacterial genomic DNA extraction and subjected to SFB 16S rRNA-specific PCR detection. The results showed SFB colonization to be age-dependent in humans, with the majority of individuals colonized within the first 2 years of life, but this colonization disappeared by the age of 3 years. Results of 16S rRNA sequencing showed that multiple operational taxonomic units of SFB could exist in the same individuals. Cross-species comparison among human, mouse and chicken samples demonstrated that each host possessed an exclusive predominant SFB sequence. In summary, our results showed that SFB display host specificity, and SFB colonization, which occurs early in human life, declines in an age-dependent manner.
Authors:
Yeshi Yin; Yu Wang; Liying Zhu; Wei Liu; Ningbo Liao; Mizu Jiang; Baoli Zhu; Hongwei D Yu; Charlie Xiang; Xin Wang
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  The ISME journal     Volume:  7     ISSN:  1751-7370     ISO Abbreviation:  ISME J     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2014-01-30     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  101301086     Medline TA:  ISME J     Country:  England    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Animals
Biodiversity*
Chickens / microbiology
Child
Child, Preschool
Feces / microbiology
Female
Gastrointestinal Contents / microbiology*
Gastrointestinal Tract / microbiology
Genetic Variation
Gram-Positive Bacteria / classification,  genetics,  physiology*
Humans
Infant
Infant, Newborn
Male
Mice
Middle Aged
Molecular Sequence Data
Phylogeny
RNA, Ribosomal, 16S / genetics
Young Adult
Chemical
Reg. No./Substance:
0/RNA, Ribosomal, 16S
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